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Retinoic acid inhibits interleukin-1 induced cytokine synthesis in human monocytes

Academic Article
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Overview

authors

  • Gross, V.
  • Villiger, P. M.
  • Zhang, B. P.
  • Lotz, Martin

publication date

  • August 1993

journal

  • Journal of Leukocyte Biology  Journal

abstract

  • Retinoids are pluripotent morphogens whose effects on gene expression are mediated through specific intracellular receptors. They have certain anti-inflammatory effects in vivo, the basis of which is not clearly understood. To characterize mechanisms involved with potential anti-inflammatory actions of retinoids, we studied the effects of retinoic acid (RA) on cytokine production in human peripheral blood monocytes. RA differentially modulated the expression of interleukin-1 beta (IL-1 beta), IL-6, and IL-8 mRNAs depending on the inducing stimulus. While phorbol myristate acetate-induced IL-1 beta and IL-8 mRNA expression was increased by RA (IL-6 could not be induced by this pathway in monocytes), IL-1 beta-induced expression of IL-1 beta and IL-8 was markedly reduced and IL-6 gene expression was almost completely suppressed. Lipopolysaccharide (LPS)-induced cytokine synthesis was only slightly reduced and this required a longer preincubation (> 72 h) of monocytes with RA. IL-1-induced de novo synthesis of IL-6 protein and secretion of biologically active IL-6 were also inhibited by RA. The inhibition pattern of RA was different from that of dexamethasone, which inhibited both IL-1 and LPS effects. In summary, our data show that RA regulates monocyte cytokine expression selectively in response to the particular stimuli. Inhibition of IL-1 beta-induced cytokine expression provides a mechanism that can explain some of the anti-inflammatory effects of RA.

subject areas

  • Base Sequence
  • Humans
  • In Vitro Techniques
  • Interleukin-1
  • Interleukin-6
  • Interleukin-8
  • Interleukins
  • Molecular Sequence Data
  • Monocytes
  • RNA, Messenger
  • Tretinoin
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Research

keywords

  • CYTOKINES
  • MONONUCLEAR PHAGOCYTES
  • RETINOIC ACID
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Identity

International Standard Serial Number (ISSN)

  • 0741-5400

PubMed ID

  • 8360592
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Additional Document Info

start page

  • 125

end page

  • 132

volume

  • 54

issue

  • 2

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