recent publications
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academic article
- Tardif, V., Manenkova, Y., Berger, M., Hoebe, K., Zuo, J. P., Yuan, C., Kono, D. H., Theofilopoulos, A. N., Lawson, B. R. Critical role of transmethylation in TLR signaling and systemic lupus erythematosus Clinical Immunology 2013 147:133-143 DOI:10.1016/j.clim.2013.02.018 PMID:23583916 PMCID:PMC3634912
- Arnold, C. N., Barnes, M. J., Berger, M., Blasius, A. L., Brandl, K., Croker, B., Crozat, K., Du, X., Eidenschenk, C., Georgel, P., Hoebe, K., Huang, H., et al. ENU-induced phenovariance in mice: Inferences from 587 mutations BMC Research Notes 2012 5:577 DOI:10.1186/1756-0500-5-577 PMID:23095377 PMCID:PMC3532239
- Barnes, M. J., Aksoylar, H., Krebs, P., Bourdeau, T., Arnold, C. N., Xia, Y., Khovananth, K., Engel, I., Sovath, S., Lampe, K., Laws, E., Saunders, A., et al. Loss of t cell and b cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in gimap5-deficient mice Journal of Immunology 2010 184:3743-3754 DOI:10.4049/jimmunol.0903164 PMID:20190135 PMCID:PMC4395861
- Jimenez-Dalmaroni, M. J., Xiao, N. M., Corper, A. L., Verdino, P., Ainge, G. D., Larsen, D. S., Painter, G. F., Rudd, P. M., Dwek, R. A., Hoebe, K., Beutler, B., Wilson, I. A. Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2 PLoS One 2009 4:e7411 DOI:10.1371/journal.pone.0007411 PMID:19847289 PMCID:PMC2760212
- Krebs, P., Barnes, M. J., Lampe, K., Whitley, K., Bahjat, K. S., Beutler, B., Janssen, E., Hoebe, K. Nk cell-mediated killing of target cells triggers robust antigen-specific t cell-mediated and humoral responses Blood 2009 113:6593-6602 DOI:10.1182/blood-2009-01-201467 PMID:19406986 PMCID:PMC2710917
- Barnes, M. J., Krebs, P., Harris, N., Eidenschenk, C., Gonzalez-Quintial, R., Arnold, C. N., Crozat, K., Sovath, S., Moresco, E. M., Theofilopoulos, A. N., Beutler, B., Hoebe, K. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery PLoS Biology 2009 7:e1000051 DOI:10.1371/journal.pbio.1000051 PMID:19260764 PMCID:PMC2650725
- Chaix, J., Tessmer, M. S., Hoebe, K., Fuseri, N., Ryffel, B., Dalod, M., Alexopoulou, L., Beutler, B., Brossay, L., Vivier, E., Walzer, T. Cutting edge: Priming of NK cells by IL-18 Journal of Immunology 2008 181:1627-1631 PMID:18641298
- Hoebe, K., Beutler, B. Forward genetic analysis of TLR-signaling pathways: an evaluation Advanced Drug Delivery Reviews 2008 60:824-829 DOI:10.1016/j.addr.2008.02.002 PMID:18331766
- Huang, Y. H., Hoebe, K., Sauer, K. New therapeutic targets in immune disorders: Itpkb, orai1 and unc93b Expert Opinion on Therapeutic Targets 2008 12:391-413 DOI:10.1517/14728222.12.4.391 PMID:18348677
- Georgel, P., Du, X., Hoebe, K., Beutler, B. ENU mutagenesis in mice Methods in Molecular Biology 2008 415:1-16 DOI:10.1007/978-1-59745-570-1_1 PMID:18370145
- Georgel, P., Jiang, Z. F., Kunz, S., Janssen, E., Mols, J., Hoebe, K., Bahram, S., Oldstone, M. B. A., Beutler, B. Vesicular stomatitis virus glycoprotein g activates a specific antiviral toll-like receptor 4-dependent pathway Virology 2007 362:304-313 DOI:10.1016/j.virol.2006.12.032 PMID:17292937
- Baccala, R., Hoebe, K., Kono, D. H., Beutler, B., Theofilopoulos, A. N. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity Nature Medicine 2007 13:543-551 DOI:10.1038/nm1590 PMID:17479100
- Brinkmann, M. M., Spooner, E., Hoebe, K., Beutler, B., Ploegh, H. L., Kim, Y. M. The interaction between the er membrane protein unc93b and tlr3, 7, and 9 is crucial for tlr signaling Journal of Cell Biology 2007 177:265-275 DOI:10.1083/jcb.200612056 PMID:17452530 PMCID:PMC2064135
- Crozat, K., Hoebe, K., Ugolini, S., Hong, N. A., Janssen, E., Rutschmann, S., Mudd, S., Sovath, S., Vivier, E., Beutler, B. Jinx, an mcmv susceptibility phenotype caused by disruption of unc13d: A mouse model of type 3 familial hemophagocytic lymphohistiocytosis Journal of Experimental Medicine 2007 204:853-863 DOI:10.1084/jem.20062447 PMID:17420270 PMCID:PMC2118559
- Gavin, A. L., Hoebe, K., Duong, B., Ota, T., Martin, C., Beutler, B., Nemazee, D. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling Science 2006 314:1936-1938 DOI:10.1126/science.1135299 PMID:17185603 PMCID:PMC1868398
- Togbe, D., Aurore, G., Noulin, N., Quesniaux, V. F. J., Schnyder-Candrian, S., Schnyder, B., Vasseur, V., Akira, S., Hoebe, K., Beutler, B., Ryffel, B., Couillin, I. Nonredundant roles of tirap and myd88 in airway response to endotoxin, independent of trif, il-1 and il-18 pathways Laboratory Investigation 2006 86:1126-1135 DOI:10.1038/labinvest.3700473 PMID:16983331
- Casrouge, A., Zhang, S. Y., Eidenschenk, C., Jouanguy, E., Puel, A., Yang, K., Alcais, A., Picard, C., Mahfoufi, N., Nicolas, N., Lorenzo, L., Plancoulaine, S., et al. Herpes simplex virus encephalitis in human unc-93b deficiency Science 2006 314:308-312 DOI:10.1126/science.1128346 PMID:16973841
- Kinjo, Y., Tupin, E., Wu, D., Fujio, M., Garcia-Navarro, R., Benhnia, Mrei, Zajonc, D. M., Ben-Menachem, G., Ainge, G. D., Painter, G. F., Khurana, A., Hoebe, K., et al. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria Nature Immunology 2006 7:978-986 DOI:10.1038/ni1380 PMID:16921381
- Rutschmann, S., Hoebe, K., Zalevsky, J., Du, X., Mann, N., Dahiyat, B. I., Steed, P., Beutler, B. PanR1, a dominant negative missense allele of the gene encoding TNF-alpha (Tnf), does not impair lymphoid development Journal of Immunology 2006 176:7525-7532 PMID:16751399
- Janssen, E., Tabeta, K., Barnes, M. J., Rutschmann, S., McBride, S., Bahjat, K. S., Schoenberger, S. P., Theofilopoulos, A. N., Beutler, B., Hoebe, K. Efficient t cell activation via a toll-interleukin 1 receptor-independent pathway Immunity 2006 24:787-799 DOI:10.1016/j.immuni.2006.03.024 PMID:16782034
- Nemazee, D., Gavin, A., Hoebe, K., Beutler, B. Immunology: Toll-like receptors and antibody responses Nature 2006 441:E4 DOI:10.1038/nature04875 PMID:16710369 PMCID:PMC3787862
- Crozat, K., Georgel, P., Rutschmann, S., Mann, N., Du, X., Hoebe, K., Beutler, B. Analysis of the MCMV resistome by ENU mutagenesis Mammalian Genome 2006 17:398-406 DOI:10.1007/s00335-005-0164-2 PMID:16688530
- Hoebe, K., Beutler, B. Traf3: A new component of the tlr-signaling apparatus Trends in Molecular Medicine 2006 12:187-189 DOI:10.1016/j.molmed.2006.03.008 PMID:16621716
- Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., Shamel, L., Herskovits, A. A., et al. The unc93b1 mutation 3d disrupts exogenous antigen presentation and signaling via toll-like receptors 3, 7 and 9 Nature Immunology 2006 7:156-164 DOI:10.1038/ni1297 PMID:16415873
- Beutler, B., Jiang, Z. F., Georgel, P., Crozat, K., Croker, B., Rutschmann, S., Du, X., Hoebe, K. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large Annual Review of Immunology 2006 24:353-389 DOI:10.1146/annurev.immunol.24.021605.090552 PMID:16551253
- Hoebe, K., Jiang, Z., Georgel, P., Tabeta, K., Janssen, E., Du, X., Beutler, B. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy Current Pharmaceutical Design 2006 12:4123-4134 DOI:10.2174/138161206778743466 PMID:17100615
- Wieland, C. W., Florquin, S., Maris, N. A., Hoebe, K., Beutler, B., Takeda, K., Akira, S., van der Poll, T. The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable Haemophilus influenzae from the mouse lung Journal of Immunology 2005 175:6042-6049 PMID:16237099
- Georgel, P., Crozat, K., Lauth, X., Makrantonaki, E., Seltmann, H., Sovath, S., Hoebe, K., Du, X., Rutschmann, S., Jiang, Z. F., Bigby, T., Nizet, V., et al. A toll-like receptor 2-responsive lipid effector pathway protects mammals against skin infections with gram-positive bacteria Infection and Immunity 2005 73:4512-4521 DOI:10.1128/iai.73.8.4512-4521.2005 PMID:16040962
- Kim, K. I., Malakhova, O. A., Hoebe, K., Yan, M., Beutler, B., Zhang, D. E. Enhanced antibacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type IIFN signaling Journal of Immunology 2005 175:847-854 PMID:16002682
- Zhou, Z. P., Hoebe, K., Du, X., Jiang, Z. F., Shamel, L., Beutler, B. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 up-regulation European Journal of Immunology 2005 35:1918-1927 DOI:10.1002/eji.200525971 PMID:15884053
- Hoebe, K., Beutler, B. Unraveling innate immunity using large scale n-ethyl-n-nitrosourea mutagenesis Tissue Antigens 2005 65:395-401 DOI:10.1111/j.1399-0039.2005.00369.x PMID:15853894
- Mattner, J., DeBord, K. L., Ismail, N., Goff, R. D., Cantu, C., Zhou, D. P., Saint-Mezard, P., Wang, V., Gao, Y., Yin, N., Hoebe, K., Schneewind, O., et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections Nature 2005 434:525-529 DOI:10.1038/nature03408 PMID:15791258
- Hoebe, K., Georgel, P., Rutschmann, S., Du, X., Mudd, S., Crozat, K., Sovath, S., Shamel, L., Hartung, T., Zahringer, U., Beutler, B. Cd36 is a sensor of diacylglycerides Nature 2005 433:523-527 DOI:10.1038/nature03253 PMID:15690042
- Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Identification and function of the tir adapter proteins Advances in Experimental Medicine and Biology 2005 560:29-39 DOI:10.1007/0-387-24180-9_4 PMID:15934170
- Beutler, B., Hoebe, K., Georgel, P., Tabeta, K., Du, X. Genetic analysis of innate immunity: Tir adapter proteins in innate and adaptive immune responses Microbes and Infection 2004 6:1374-1381 DOI:10.1016/j.micinf.2004.08.017 PMID:15596123
- Hoebe, K., Janssen, E., Beutler, B. The interface between innate and adaptive immunity Nature Immunology 2004 5:971-974 DOI:10.1038/ni1004-971 PMID:15454919
- Anfossi, N., Robbins, S. H., Ugolini, S., Georgel, P., Hoebe, K., Bouneaud, C., Ronet, C., Kaser, A., DiCioccio, C. B., Tomasello, E., Blumberg, R. S., Beutler, B., et al. Expansion and function of CD8(+) T cells, expressing Ly49 inhibitory receptors specific for MHC class I molecules Journal of Immunology 2004 173:3773-3782 PMID:15356124
- Beutler, B., Hoebe, K., Shamel, L. Forward genetic dissection of afferent immunity: The role of tir adapter proteins in innate and adaptive immune responses Comptes Rendus Biologies 2004 327:571-580 DOI:10.1016/j.crvi.2004.03.008 PMID:15330256
- Tabeta, K., Georgel, P., Janssen, E., Du, X., Hoebe, K., Crozat, K., Mudd, S., Shamel, L., Sovath, S., Goode, J., Alexopoulou, L., Flavell, R. A., et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection Proceedings of the National Academy of Sciences of the United States of America 2004 101:3516-3521 DOI:10.1073/pnas.0400525101 PMID:14993594 PMCID:PMC373494
- Weighardt, H., Jusek, G., Mages, J., Lang, R., Hoebe, K., Beutler, B., Holzmann, B. Identification of a tlr4- and trif-dependent activation program of dendritic cells European Journal of Immunology 2004 34:558-564 DOI:10.1002/eji.200324714 PMID:14768061
- Hoebe, K., Beutler, B. Lps, dsrna and the interferon bridge to adaptive immune responses: Trif, tram, and other tir adaptor proteins Journal of Endotoxin Research 2004 10:130-136 DOI:10.1179/096805104225004031 PMID:15120005
- Du, X., Tabeta, K., Hoebe, K., Liu, H. Q., Mann, N., Mudd, S., Crozat, K., Sovath, S., Gong, X. H., Beutler, B. Velvet, a dominant egfr mutation that causes wavy hair and defective eyelid development in mice Genetics 2004 166:331-340 DOI:10.1534/genetics.166.1.331 PMID:15020428
- Hoebe, K., Janssen, E. M., Kim, S. O., Alexopoulou, L., Flavell, R. A., Han, J. H., Beutler, B. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded rna occurs by trif-dependent and trif-independent pathways Nature Immunology 2003 4:1223-1229 DOI:10.1038/ni1010 PMID:14625548
- Beutler, B., Hoebe, K., Du, X., Ulevitch, R. J. How we detect microbes and respond to them: The toll-like receptors and their transducers Journal of Leukocyte Biology 2003 74:479-485 DOI:10.1189/jlb.0203082 PMID:12960260
- Beutler, B., Hoebe, K., Du, X., Janssen, E., Georgel, P., Tabeta, K. Lps2 and signal transduction in sepsis: At the intersection of host responses to bacteria and viruses Scandinavian Journal of Infectious Diseases 2003 35:563-567 DOI:10.1080/00365540310016295 PMID:14620135
- Hoebe, K., Du, X., Georgel, P., Janssen, E., Tabeta, K., Kim, S. O., Goode, J., Lin, P., Mann, N., Mudd, S., Crozat, K., Sovath, S., et al. Identification of lps2 as a key transducer of myd88-independent tir signalling Nature 2003 424:743-748 DOI:10.1038/nature01889 PMID:12872135
- Beutler, B., Du, X., Hoebe, K. From phenomenon to phenotype and from phenotype to gene: Forward genetics and the problem of sepsis Journal of Infectious Diseases 2003 187:S321-S326 DOI:10.1086/374757 PMID:12792846
- Kim, S. O., Jing, Q., Hoebe, K., Beutler, B., Duesbery, N. S., Han, J. H. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-alpha Journal of Biological Chemistry 2003 278:7413-7421 DOI:10.1074/jbc.M209279200 PMID:12488448
- Hoebe, K., Du, X., Goode, J., Mann, N., Beutler, B. Lps2: A new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening Journal of Endotoxin Research 2003 9:250-255 DOI:10.1179/096805103225001459 PMID:12935356