Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Pertussis toxin-sensitive G-protein mediates galanin's inhibition of scopolamine-evoked acetylcholine release in vivo and carbachol-stimulated phosphoinositide turnover in rat ventral hippocampus

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Consolo, S.
  • Bertorelli, R.
  • Girotti, P.
  • Laporta, C.
  • Bartfai, Tamas
  • Parenti, M.
  • Zambelli, M.

publication date

  • May 1991

journal

  • Neuroscience Letters  Journal

abstract

  • The effects of intracerebroventricular (i.c.v.) injections of pertussis toxin were investigated on the inhibitory action of galanin on acetylcholine release and phosphoinositide breakdown stimulated by muscarinic agents in rat ventral hippocampus. Pertussis toxin (0.6 micrograms, i.c.v., 96 h) counteracted the in vitro inhibitory effect of galanin (3.1 nmol) on phosphoinositide breakdown stimulated by carbachol without altering the stimulatory action of the cholinergic agonist on signal transduction, in miniprisms from rat ventral hippocampus. Pertussis toxin also abolished the in vivo effect of galanin on scopolamine-stimulated acetylcholine release in vivo but did not affect basal acetylcholine release. The results indicate that pertussis toxin-sensitive G-protein(s) mediates the galanin receptor regulation of pre- and postsynaptic cholinergic functions in the ventral hippocampus.

subject areas

  • Acetylcholine
  • Animals
  • Carbachol
  • Cell Membrane
  • Cerebral Ventricles
  • GTP-Binding Proteins
  • Galanin
  • Hippocampus
  • Injections, Intraventricular
  • Male
  • Neuropeptides
  • Peptides
  • Pertussis Toxin
  • Phosphatidylinositols
  • Rats
  • Rats, Inbred Strains
  • Reference Values
  • Scopolamine Hydrobromide
  • Virulence Factors, Bordetella
scroll to property group menus

Research

keywords

  • ACETYLCHOLINE RELEASE INVIVO
  • G-PROTEIN
  • GALANIN
  • MICRODIALYSIS
  • PHOSPHOINOSITIDE BREAKDOWN
  • RAT VENTRAL HIPPOCAMPUS
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/0304-3940(91)90363-x

PubMed ID

  • 1714064
scroll to property group menus

Additional Document Info

start page

  • 29

end page

  • 32

volume

  • 126

issue

  • 1

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support