Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

A major histocompatibility complex class I-dependent subset of memory phenotype CD8(+) cells

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Boyman, O.
  • Cho, J. H.
  • Tan, J. T.
  • Surh, Charles
  • Sprent, Jonathan

publication date

  • July 2006

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Most memory phenotype (MP) CD44(hi) CD8(+) cells are resting interleukin (IL)-15-dependent cells characterized by high expression of the IL-2/IL-15 receptor beta (CD122). However, some MP CD8(+) cells have a CD122(lo) phenotype and are IL-15 independent. Here, evidence is presented that the CD122(lo) subset of MP CD8(+) cells is controlled largely by major histocompatibility complex (MHC) class I molecules. Many of these cells display surface markers typical of recently activated T cells (CD62L(lo), CD69(hi), CD43(hi), and CD127(lo)) and show a high rate of background proliferation. Cells with this phenotype are highly enriched in common gamma chain-deficient mice and absent from MHC-I(-/-) mice. Unlike CD122(hi) CD8(+) cells, CD122(lo) MP CD8(+) cells survive poorly after transfer to MHC-I(-/-) hosts and cease to proliferate. Although distinctly different from typical antigen-specific memory cells, CD122(lo) MP CD8(+) cells closely resemble the antigen-dependent memory CD8(+) cells found in chronic viral infections.

subject areas

  • Animals
  • CD8-Positive T-Lymphocytes
  • Cystatin C
  • Cystatins
  • Histocompatibility Antigens Class I
  • Immunologic Memory
  • Immunophenotyping
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • T-Lymphocyte Subsets
scroll to property group menus

Identity

PubMed Central ID

  • PMC2118360

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20052495

PubMed ID

  • 16818671
scroll to property group menus

Additional Document Info

start page

  • 1817

end page

  • 1825

volume

  • 203

issue

  • 7

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support