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Differential effects of morphine and cocaine on locomotor activity and sensitization in mu-opioid receptor knockout mice

Academic Article
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Overview

authors

  • Yoo, J. H.
  • Yang, E. M.
  • Lee, S. Y.
  • Loh, H. H.
  • Ho, I. K.
  • Jang, Choon-Gon

publication date

  • June 2003

journal

  • Neuroscience Letters  Journal

abstract

  • The present study was undertaken to investigate the hypothesis that the mu-opioid receptors play a crucial role in locomotor activity and sensitization to cocaine and morphine in wild-type and mu-opioid receptor knockout mice. Our results show that morphine and cocaine increased locomotor activity in wild-type mice, but failed to increase locomotor activity in mu-opioid receptor knockout mice, suggesting a contribution of mu-opioid receptor. Repeated morphine treatment induced sensitization in wild-type mice, but this was not observed in mu-opioid receptor knockout mice. In contrast repeated cocaine treatment produced sensitization in mu-opioid receptor knockout mice, but not in wild-type mice on day 6. However, the sensitization to cocaine was observed in mu-opioid receptor knockout and wild-type mice on day 12. These results suggest that the expression of mu-opioid receptor may contribute to locomotor sensitization induced by morphine, but that mu-opioid receptor does not play an important role in mediating sensitization to cocaine.

subject areas

  • Adaptation, Physiological
  • Animals
  • Cocaine
  • Dopamine Uptake Inhibitors
  • Mice
  • Mice, Knockout
  • Morphine
  • Motor Activity
  • Narcotics
  • Receptors, Opioid, mu
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Identity

International Standard Serial Number (ISSN)

  • 0304-3940

Digital Object Identifier (DOI)

  • 10.1016/s0304-3940(03)00410-5

PubMed ID

  • 12781916
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Additional Document Info

start page

  • 37

end page

  • 40

volume

  • 344

issue

  • 1

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