Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Relation of temporal creatine kinase-mb release and outcome after thrombolytic therapy for acute myocardial infarction

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Christenson, R. H.
  • Vollmer, R. T.
  • Ohman, E. M.
  • Peck, S.
  • Thompson, T. D.
  • Duh, S. H.
  • Ellis, S. G.
  • Newby, L. K.
  • Topol, Eric
  • Califf, R. M.
  • Grp, Tami Study

publication date

  • 2000

journal

  • American Journal of Cardiology  Journal

abstract

  • Measuring biochemical marker release after acute myocardial infarction helps in estimating infarct size and prognosis. We sought to relate in-hospital outcomes and curve-fitted creatine kinase (CK)-MB variables after thrombolysis. We measured CK-MB mass initially and at 30 and 90 minutes, and at 3, 8, and 20 hours after thrombolysis in 130 patients also undergoing cardiac catheterization at 90 minutes and at 5 to 7 days. Data were fitted, and maximums and curve areas calculated. CK-MB maximums related to infarct location (p = 0.014) and time to therapy (p = 0.002); curve area did not. Neither maximums nor curve area related to Thrombolysis in Myocardial Infarction trial flow grade at 90 minutes. Maximums related to ejection fraction at 90 minutes (p = 0.0004) and at 5 to 7 days (p = 0.0014), as did curve area (p = 0.0076 and 0.030, respectively). Maximums related to infarct zone function at 90 minutes (p = 0.024) and at 5 to 7 days (p = 0.042); curve area related only at 90 minutes (p = 0.027). Both maximums and curve area predicted congestive heart failure (p = 0.008 and p = 0.042, respectively) and a composite of congestive heart failure or death (p = 0.004 and p = 0.047, respectively); however, after adjusting for maximums, curve area no longer predicted congestive heart failure (p = 0.92). Maximums predicted the composite outcome after adjustment for curve area, and showed a trend toward predicting congestive heart failure (p = 0.089). We conclude that CK-MB maximums relate to infarct zone function, left ventricular function, and in-hospital outcomes after thrombolysis for acute myocardial infarction.

subject areas

  • Biomarkers
  • Cardiac Catheterization
  • Creatine Kinase
  • Creatine Kinase, MB Form
  • Female
  • Fibrinolytic Agents
  • Heart Failure
  • Humans
  • Isoenzymes
  • Logistic Models
  • Male
  • Middle Aged
  • Myocardial Infarction
  • Thrombolytic Therapy
  • Time Factors
  • Tissue Plasminogen Activator
  • Ventricular Function, Left
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/s0002-9149(99)00808-5

PubMed ID

  • 11078264
scroll to property group menus

Additional Document Info

start page

  • 543

end page

  • 547

volume

  • 85

issue

  • 5

©2019 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support