recent publications

• academic article

  • Frankowski, K. J., Slauson, S. R., Lovell, K. M., Phillips, A. M., Streicher, J. M., Zhou, L., Whipple, D. A., Schoenen, F. J., Prisinzano, T. E., Bohn, L. M., Aube, J. Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif Bioorganic & Medicinal Chemistry  2015 23:3948-3956  DOI:10.1016/j.bmc.2014.12.033  PMID:25593096  PMCID:PMC4468036
  • Lovell, K. M., Frankowski, K. J., Stahl, E. L., Slauson, S. R., Yoo, E., Prisinzano, T. E., Aubé, J., Bohn, L. M. Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias ACS Chemical Neuroscience  2015 6:1411-1419  DOI:10.1021/acschemneuro.5b00092  PMID:25891774  PMCID:PMC4830356
  • Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., Stahl, E., Schmid, C. L., Hodder, P., Madoux, F., Cameron, M. D., Prisinzano, T. E., et al. Development of functionally selective, small molecule agonists at kappa opioid receptors Journal of Biological Chemistry  2013 288:36703-36716  DOI:10.1074/jbc.M113.504381  PMID:24187130  PMCID:PMC3868780
  • Lamb, K., Tidgewell, K., Simpson, D. S., Bohn, L. M., Prisinzano, T. E. Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology: From a symposium on new concepts in mu-opioid pharmacology Drug and Alcohol Dependence  2012 121:181-188  DOI:10.1016/j.drugalcdep.2011.10.026  PMID:22119134  PMCID:PMC3288203
  • Frankowski, K. J., Hedrick, M. P., Gosalia, P., Li, K. L., Shi, S. H., Whipple, D., Ghosh, P., Prisinzano, T. E., Schoenen, F. J., Su, Y., Vasile, S., Sergienko, E., et al. Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and Hit refinement strategy ACS Chemical Neuroscience  2012 3:221-236  DOI:10.1021/cn200128x  PMID:22737280  PMCID:PMC3378255
  • Tidgewell, K., Groer, C. E., Harding, W. W., Lozama, A., Schmidt, M., Marquam, A., Hiemstra, J., Partilla, J. S., Dersch, C. M., Rothman, R. B., Bohn, L. M., Prisinzano, T. E. Herkinorin analogues with differential beta-arrestin-2 interactions Journal of Medicinal Chemistry  2008 51:2421-2431  DOI:10.1021/jm701162g  PMID:18380425  PMCID:PMC2494883
  • Xu, H., Partilla, J. S., Wang, X. Y., Rutherford, J. M., Tidgewell, K., Prisinzano, T. E., Bohn, L. M., Rothman, R. B. A comparison of noninternalizing (herkinorin) and internalizing (DAMGO) mu-opioid agonists on cellular markers related to opioid tolerance and dependence Synapse  2007 61:166-175  DOI:10.1002/syn.20356  PMID:17152090
  • Groer, C. E., Tidgewell, K., Moyer, R. A., Harding, W. W., Rothman, R. B., Prisinzano, T. E., Bohn, L. M. An opioid agonist that does not induce mu-opioid receptor - arrestin interactions or receptor internalization Molecular Pharmacology  2007 71:549-557  DOI:10.1124/mol.106.028258  PMID:17090705  PMCID:PMC3926195