recent publications

• academic article

  • Smith, E., Chase, P., Niswender, C. M., Utley, T. J., Sheffler, D. J., Noetzel, M. J., Lamsal, A., Wood, M. R., Conn, P. J., Lindsley, C. W., Madoux, F., Acosta, M., et al. Application of parallel multiparametric cell-based FLIPR detection assays for the identification of modulators of the muscarinic acetylcholine receptor 4 (M-4) Journal of Biomolecular Screening  2015 20:858-868  DOI:10.1177/1087057115581770  PMID:25877150  PMCID:PMC4659430
  • Madoux, F., Janovick, J. A., Smithson, D., Fargue, S., Danpure, C. J., Scampavia, L., Chen, Y. T., Spicer, T. P., Conn, P. M. Development of a phenotypic high-content assay to identify pharmacoperone drugs for the treatment of primary hyperoxaluria type 1 by high-throughput screening Assay and Drug Development Technologies  2015 13:16-24  DOI:10.1089/adt.2014.627  PMID:25710543
  • Wang, Y., Stowe, R. L., Pinello, C. E., Tian, G., Madoux, F., Li, D., Zhao, L. Y., Li, J. L., Wang, Y., Wang, Y., Ma, H., Hodder, P., et al. Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases Chemistry & Biology  2015 22:273-284  DOI:10.1016/j.chembiol.2014.12.015  PMID:25699604  PMCID:PMC4365786
  • Pedro-Rosa, L., Buckner, F. S., Ranade, R. M., Eberhart, C., Madoux, F., Gillespie, J. R., Koh, C. Y., Brown, S., Lohse, J., Verlinde, C. L. M., Fan, E., Bannister, T., et al. Identification of potent inhibitors of the Trypanosoma brucei methionyl-tRNA synthetase via high-throughput orthogonal screening Journal of Biomolecular Screening  2015 20:122-130  DOI:10.1177/1087057114548832  PMID:25163684  PMCID:PMC4378865
  • Lewallen, D. M., Bicker, K. L., Madoux, F., Chase, P., Anguish, L., Coonrod, S., Hodder, P., Thompson, P. R. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs ACS Chemical Biology  2014 9:913-921  DOI:10.1021/cb400841k  PMID:24467619  PMCID:PMC4108211
  • Wang, Y., Lonard, D. M., Yu, Y., Chow, D. C., Palzkill, T. G., Wang, J., Qi, R., Matzuk, A. J., Song, X., Madoux, F., Hodder, P., Chase, P., et al. Bufalin is a potent small-molecule inhibitor of the steroid receptor coactivators SRC-3 and SRC-1 Cancer Research  2014 74:1506-1517  DOI:10.1158/0008-5472.can-13-2939  PMID:24390736  PMCID:PMC3947477
  • Penas, C., Ramachandran, V., Simanski, S., Lee, C., Madoux, F., Rahaim, R. J., Chauhan, R., Barnaby, O., Schurer, S., Hodder, P., Steen, J., Roush, W. R., et al. Casein kinase 1 delta-dependent Wee1 protein degradation Journal of Biological Chemistry  2014 289:18893-18903  DOI:10.1074/jbc.M114.547661  PMID:24817118  PMCID:PMC4081930
  • Madoux, F., Tredup, C., Scampavia, L., Chase, P. S., Hodder, P. S., Fields, G. B., Becker-Pauly, C., Minond, D., Spicer, T. P. Development of high throughput screening assays and pilot screen for inhibitors of metalloproteases meprin α and β Biopolymers  2014 102:396-406  DOI:10.1002/bip.22527  PMID:25048711  PMCID:PMC4339026
  • Yan, F., Yu, Y., Chow, D. C., Palzkill, T., Madoux, F., Hodder, P., Chase, P., Griffin, P. R., O'Malley, B. W., Lonard, D. M. Identification of verrucarin a as a potent and selective steroid receptor coactivator-3 small molecule inhibitor PLoS One  2014 9:e95243  DOI:10.1371/journal.pone.0095243  PMID:24743578  PMCID:PMC3990629
  • Lewallen, D. M., Sreelatha, A., Dharmarajan, V., Madoux, F., Chase, P., Griffin, P. R., Orth, K., Hodder, P., Thompson, P. R. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation ACS Chemical Biology  2014 9:433-442  DOI:10.1021/cb4006886  PMID:24274060  PMCID:PMC3944102
  • Zhou, L., Lovell, K. M., Frankowski, K. J., Slauson, S. R., Phillips, A. M., Streicher, J. M., Stahl, E., Schmid, C. L., Hodder, P., Madoux, F., Cameron, M. D., Prisinzano, T. E., et al. Development of functionally selective, small molecule agonists at kappa opioid receptors Journal of Biological Chemistry  2013 288:36703-36716  DOI:10.1074/jbc.M113.504381  PMID:24187130  PMCID:PMC3868780
  • Qin, Q., Knapinska, A., Dobri, N., Madoux, F., Chase, P., Hodder, P., Petrukhin, K. In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3 Journal of Ocular Pharmacology and Therapeutics  2013 29:298-309  DOI:10.1089/jop.2012.0135  PMID:23098562  PMCID:PMC3613967
  • Calamini, B., Silva, M. C., Madoux, F., Hutt, D. M., Khanna, S., Chalfant, M. A., Saldanha, S. A., Hodder, P., Tait, B. D., Garza, D., Balch, W. E., Morimoto, R. I. Small-molecule proteostasis regulators for protein conformational diseases Nature Chemical Biology  2012 8:185-196  DOI:10.1038/nchembio.763  PMID:22198733  PMCID:PMC3262058
  • Bialkowska, A. B., Crisp, M., Bannister, T., He, Y. J., Chowdhury, S., Schurer, S., Chase, P., Spicer, T., Madoux, F., Tian, C. L., Hodder, P., Zaharevitz, D., et al. Identification of small-molecule inhibitors of the colorectal cancer oncogene Kruppel-like factor 5 expression by ultrahigh-throughput screening Molecular Cancer Therapeutics  2011 10:2043-2051  DOI:10.1158/1535-7163.mct-11-0550  PMID:21885866  PMCID:PMC3213326
  • Madoux, F., Simanski, S., Chase, P., Mishra, J. K., Roush, W. R., Ayad, N. G., Hodder, P. An ultra-high throughput cell-based screen for wee1 degradation inhibitors Journal of Biomolecular Screening  2010 15:907-917  DOI:10.1177/1087057110375848  PMID:20660794  PMCID:PMC3082437
  • Doghman, M., Cazareth, J., Douguet, D., Madoux, F., Hodder, P., Lalli, E. Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists Journal of Clinical Endocrinology & Metabolism  2009 94:2178-2183  DOI:10.1210/jc.2008-2163  PMID:19318454  PMCID:PMC2690427
  • Madoux, F., Li, X. L., Chase, P., Zastrow, G., Cameron, M. D., Conkright, J. J., Griffin, P. R., Thacher, S., Hodder, P. Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening Molecular Pharmacology  2008 73:1776-1784  DOI:10.1124/mol.108.045963  PMID:18334597  PMCID:PMC3228235
  • Roth, J., Madoux, F., Hodder, P., Roush, W. R. Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds Bioorganic & Medicinal Chemistry Letters  2008 18:2628-2632  DOI:10.1016/j.bmcl.2008.03.027  PMID:18374567  PMCID:PMC2592603

• report

  • Bialkowska, A., Crisp, M., Madoux, F., Spicer, T., Knapinska, A., Mercer, B., Bannister, T. D., He, Y., Chowdhury, S., Cameron, M., Yang, V. W., Hodder, P. ML264: An antitumor agent that potently and selectively inhibits kruppel-like factor five (KLF5) expression: a probe for studying colon cancer development and progression Probe Reports from the NIH Molecular Libraries Program. 2010  PMID:23762940