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Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

Academic Article
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Overview

related to degree

  • Duong, Bao Hoa, Ph.D. in Macromolecular and Cellular Structure and Chemistry, Scripps Research 2003 - 2009
  • Vela, Jose L, Ph.D. in Immunology, Scripps Research 2001 - 2007

authors

  • Duong, Bao Hoa
  • Tian, H.
  • Ota, Takayuki
  • Completo, G.
  • Han, S. F.
  • Vela, Jose L
  • Ota, M.
  • Kubitz, M.
  • Bovin, N.
  • Paulson, James
  • Nemazee, David

publication date

  • 2010

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Autoreactive B lymphocytes first encountering self-antigens in peripheral tissues are normally regulated by induction of anergy or apoptosis. According to the "two-signal" model, antigen recognition alone should render B cells tolerant unless T cell help or inflammatory signals such as lipopolysaccharide are provided. However, no such signals seem necessary for responses to T-independent type 2 (TI-2) antigens, which are multimeric antigens lacking T cell epitopes and Toll-like receptor ligands. How then do mature B cells avoid making a TI-2-like response to multimeric self-antigens? We present evidence that TI-2 antigens decorated with ligands of inhibitory sialic acid-binding Ig-like lectins (siglecs) are poorly immunogenic and can induce tolerance to subsequent challenge with immunogenic antigen. Two siglecs, CD22 and Siglec-G, contributed to tolerance induction, preventing plasma cell differentiation or survival. Although mutations in CD22 and its signaling machinery have been associated with dysregulated B cell development and autoantibody production, previous analyses failed to identify a tolerance defect in antigen-specific mutant B cells. Our results support a role for siglecs in B cell self-/nonself-discrimination, namely suppressing responses to self-associated antigens while permitting rapid "missing self"-responses to unsialylated multimeric antigens. The results suggest use of siglec ligand antigen constructs as an approach for inducing tolerance.

subject areas

  • Animals
  • Antibody Formation
  • Autoantibodies
  • Autoantigens
  • Cell Differentiation
  • Cell Survival
  • Immune Tolerance
  • Inflammation
  • Lectins
  • Ligands
  • Mice
  • Mice, Knockout
  • Plasma Cells
  • Receptors, Antigen, B-Cell
  • Sialic Acid Binding Ig-like Lectin 2
  • Signal Transduction
  • T-Lymphocytes, Helper-Inducer
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Identity

PubMed Central ID

  • PMC2812539

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.20091873

PubMed ID

  • 20038598
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Additional Document Info

start page

  • 173

end page

  • 187

volume

  • 207

issue

  • 1

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