Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Role of sensitized cells in antitubular basement membrane interstitial nephritis

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Lehman, D. H.
  • Wilson, Curtis

publication date

  • 1976

journal

  • International Archives of Allergy and Applied Immunology  Journal

abstract

  • The pathogenic effect of antitubular basement membrane (TBM) antibodies in anti-TBM interstitial nephritis has been demonstrated. To determine the relative role of sensitized cells in inducing this lesion, lymph node cells (LNC) alone or a combination of LNC and peritoneal exudate cells were transferred from Brown Norway (BN) rats, previously immunized with TBM into unimmunized BN-recipient rats. Cells were transferred directly under the recipients' renal capsules. Although significant tubular lesions were induced by the cells, the lesions were usually mild and always focal. Hence, sensitized cells do not appear to be central to the pathogenesis of anti-TBM nephritis.

subject areas

  • Animals
  • Basement Membrane
  • Female
  • Immunity, Cellular
  • Kidney Tubules
  • Lymphocytes
  • Male
  • Nephritis, Interstitial
  • Rats
  • Rats, Inbred BN
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0020-5915

Digital Object Identifier (DOI)

  • 10.1159/000231589

PubMed ID

  • 1279020
scroll to property group menus

Additional Document Info

start page

  • 168

end page

  • 174

volume

  • 51

issue

  • 2

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support