recent publications

• academic article

  • Friese, R. S., Altshuler, A. E., Zhang, K., Miramontes-Gonzalez, J. P., Hightower, C. M., Jirout, M. L., Salem, R. M., Gayen, J. R., Mahapatra, N. R., Biswas, N., Cale, M., Vaingankar, S. M., et al. MicroRNA-22 and promoter motif polymorphisms at the Chga locus in genetic hypertension: functional and therapeutic implications for gene expression and the pathogenesis of hypertension Human Molecular Genetics  2013 22:3624-3640  DOI:10.1093/hmg/ddt213  PMID:23674521  PMCID:PMC3749858
  • Fung, M. M., Salem, R. M., Lipkowitz, M. S., Bhatnagar, V., Pandey, B., Schork, N. J., O'Connor, D. T., Investigators, Aask Study Methylenetetrahydrofolate reductase (mthfr) polymorphism a1298c (glu429ala) predicts decline in renal function over time in the african-american study of kidney disease and hypertension (aask) trial and veterans affairs hypertension cohort (vahc) Nephrology, Dialysis, Transplantation  2012 27:197-205  DOI:10.1093/ndt/gfr257  PMID:21613384  PMCID:PMC3350339
  • Salem, R. M., Pandey, B., Richard, E., Fung, M. M., Garcia, E. P., Brophy, V. H., Schork, N. J., O'Connor, D. T., Bhatnagar, V. The va hypertension primary care longitudinal cohort: Electronic medical records in the post-genomic era Health Informatics Journal  2010 16:274-286  DOI:10.1177/1460458210380527  PMID:21216807  PMCID:PMC3099595
  • Chen, W., Kahonen, M., Kettunen, J., Lehtimaki, T., Peltonen, L., Raitakari, O. T., Salem, R. M., Schork, N. J., Shaw, M., Srinivasan, S. R., Topol, E. J., Viikari, J. S., et al. Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study PLoS Genetics  2010 6:e1001094  DOI:10.1371/journal.pgen.1001094  PMID:20838585  PMCID:PMC2936521
  • Salem, R. M., O'Connor, D. T., Schork, N. J. Curve-based multivariate distance matrix regression analysis: Application to genetic association analyses involving repeated measures Physiological Genomics  2010 42:236-247  DOI:10.1152/physiolgenomics.00118.2009  PMID:20423962  PMCID:PMC3032281
  • Zhang, K. X., Rao, F. W., Wang, L., Rana, B. K., Ghosh, S., Mahata, M., Salem, R. M., Rodriguez-Flores, J. L., Fung, M. M., Waalen, J., Tayo, B., Taupenot, L., et al. Common functional genetic variants in catecholamine storage vesicle protein promoter motifs interact to trigger systemic hypertension Journal of the American College of Cardiology  2010 55:1463-1475  DOI:10.1016/j.jacc.2009.11.064  PMID:20359597  PMCID:PMC2889490
  • Chen, Y. Q., Salem, R. M., Rao, F. W., Fung, M. M., Bhatnagar, V., Pandey, B., Mahata, M., Waalen, J., Nievergelt, C. M., Lipkowitz, M. S., Hamilton, B. A., Mahata, S. K., et al. Common charge-shift mutation glu65lys in k(+) channel beta(1)-subunit kcnmb1: Pleiotropic consequences for glomerular filtration rate and progressive renal disease American Journal of Nephrology  2010 32:414-424  DOI:10.1159/000320131  PMID:20861615  PMCID:PMC2975731
  • Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Fung, M. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Hicks, P. J., Bowden, D. W., et al. Progression of chronic kidney disease: Adrenergic genetic influence on glomerular filtration rate decline in hypertensive nephrosclerosis American Journal of Nephrology  2010 32:23-30  DOI:10.1159/000313927  PMID:20484896  PMCID:PMC2914391
  • Fung, M. M., Chen, Y. Q., Lipkowitz, M. S., Salem, R. M., Bhatnagar, V., Mahata, M., Nievergelt, C. M., Rao, F. W., Mahata, S. K., Schork, N. J., Brophy, V. H., O'Connor, D. T., et al. Adrenergic beta-1 receptor genetic variation predicts longitudinal rate of GFR decline in hypertensive nephrosclerosis Nephrology Dialysis Transplantation  2009 24:3677-3686  DOI:10.1093/ndt/gfp471  PMID:19745105  PMCID:PMC2790952
  • Fung, M. M., Rana, B. K., Tang, C. M., Shiina, T., Nievergelt, C. M., Rao, F. W., Salem, R. M., Waalen, J., Ziegler, M. G., Insel, P. A., O'Connor, D. T. Dopamine d1 receptor (drd1) genetic polymorphism: Pleiotropic effects on heritable renal traits Kidney International  2009 76:1070-1080  DOI:10.1038/ki.2009.306  PMID:19675531  PMCID:PMC2803094
  • Bhatnagar, V., To'Connor, D., Brophy, V. H., Schork, N. J., Richard, E., Salem, R. M., Nievergelt, C. M., Bakris, G. L., Middleton, J. P., Norris, K. C., Wright, J., Hiremath, L., et al. G-protein-coupled receintor kinase 4 polymorphisms and blood pressure response to metoprolol among african americans: Sex-specificity and interactions American Journal of Hypertension  2009 22:332-338  DOI:10.1038/ajh.2008.341  PMID:19119263  PMCID:PMC2715837
  • Zhang, K. X., Rao, F. W., Rana, B. K., Gayen, J. R., Calegari, F., King, A., Rosa, P., Huttner, W. B., Stridsberg, M., Mahata, M., Vaingankar, S., Mahboubi, V., et al. Autonomic function in hypertension role of genetic variation at the catecholamine storage vesicle protein chromogranin b Circulation-Cardiovascular Genetics  2009 2:46-56  DOI:10.1161/circgenetics.108.785659  PMID:20011129  PMCID:PMC2792940
  • Chen, Y. Q., Rao, F. W., Rodriguez-Flores, J. L., Mahata, M., Fung, M. M., Stridsberg, M., Vaingankar, S. M., Wen, G., Salem, R. M., Das, M., Cockburn, M. G., Schork, N. J., et al. Naturally occurring human genetic variation in the 3 '-untranslated region of the secretory protein chromogranin a is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion Journal of the American College of Cardiology  2008 52:1468-1481  DOI:10.1016/j.jacc.2008.07.047  PMID:19017515  PMCID:PMC2659417
  • Chen, Y., Rao, F., Rodriguez-Flores, J. L., Mahapatra, N. R., Mahata, M., Wen, G., Salem, R. M., Shih, P. A. B., Das, M., Schork, N. J., Ziegler, M. G., Hamilton, B. A., et al. Common genetic variants in the chromogranin a promoter alter autonomic activity and blood pressure Kidney International  2008 74:115-125  DOI:10.1038/ki.2008.113  PMID:18432188  PMCID:PMC2576285
  • Salem, R. M., Cadman, P. E., Chen, Y., Rao, F., Wen, G., Harnilton, B. A., Rana, B. K., Smith, D. W., Stridsberg, M., Ward, H. J., Mahata, M., Mahata, S. K., et al. Chromogranin a polymorphisms are associated with hypertensive renel disease Journal of the American Society of Nephrology  2008 19:600-614  DOI:10.1681/asn.2007070754  PMID:18235090  PMCID:PMC2391050
  • Fung, M. M., Nguyen, C., Mehtani, P., Salem, R. M., Perez, B., Thomas, B., Das, M., Schork, N. J., Mahata, S. K., Ziegler, M. G., O'Connor, D. T. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans Circulation  2008 117:517-525  DOI:10.1161/circulationaha.107.706317  PMID:18180394  PMCID:PMC2628716
  • Bhatnagar, V., O'Connor, D. T., Schork, N. J., Salem, R. M., Nievergelt, C. M., Rana, B. K., Smith, D. W., Bakris, G. L., Middleton, J. P., Norris, K. C., Wright, J. T., Cheek, D., et al. Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the aask trial Journal of Hypertension  2007 25:2082-2092  DOI:10.1097/HJH.0b013e3282b9720e  PMID:17885551  PMCID:PMC2792638
  • Zhang, L., Rao, F., Zhang, K., Khandrika, S., Das, M., Vaingankar, S. M., Bao, X., Rana, B. K., Smith, D. W., Wessel, J., Salem, R. M., Rodriguez-Flores, J. L., et al. Discovery of common human genetic variants of gtp cyclohydrolase 1 (gch1) governing nitric oxide, autonomic activity, and cardiovascular risk Journal of Clinical Investigation  2007 117:2658-2671  DOI:10.1172/jci31093  PMID:17717598
  • Rao, F., Zhang, L., Wessel, J., Zhang, K., Wen, G., Kennedy, B. P., Rana, B. K., Das, M., Rodriguez-Flores, J. L., Smith, D. W., Cadman, P. E., Salem, R. M., et al. Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis - discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo Circulation  2007 116:993-1006  DOI:10.1161/circulationaha.106.682302  PMID:17698732
  • Rao, F., Wen, G., Gayen, J. R., Das, M., Vaingankar, S. M., Rana, B. K., Mahata, M., Kennedy, B. P., Salem, R. M., Stridsberg, M., Abel, K., Smith, D. W., et al. Catecholamine release-inhibitory peptide catestatin (chromogranin a(352-372)) - naturally occurring amino acid variant gly364ser causes profound changes in human autonomic activity and alters risk for hypertension Circulation  2007 115:2271-2281  DOI:10.1161/circulationaha.106.628859  PMID:17438154
  • Rao, F. W., Wessel, J., Wen, G., Zhang, L., Rana, B. K., Kennedy, B. P., Greenwood, T. A., Salem, R. M., Chen, Y. Q., Khandrika, S., Hamilton, B. A., Smith, D. W., et al. Renal albumin excretion - twin studies identify influences of heredity, environment, and adrenergic pathway polymorphism Hypertension  2007 49:1015-1031  DOI:10.1161/hypertensionaha.106.081679  PMID:17353515