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Tissue distribution of beta-3-adrenergic receptor messenger-rna in man

Academic Article
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Overview

authors

  • Krief, S.
  • Lonnqvist, F.
  • Raimbault, S.
  • Baude, B.
  • Vanspronsen, A.
  • Arner, P.
  • Strosberg, Donny
  • Ricquier, D.
  • Emorine, L. J.

publication date

  • January 1993

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Expression of mRNA for beta 1-, beta 2-, and beta 3-adrenergic receptors (beta 1-, beta 2-, and beta 3-AR) was investigated in human tissues. beta 1- and beta 2-AR mRNA distribution correlated with that of the cognate receptors established by pharmacological studies. beta 3-AR transcripts were abundant in infant perirenal brown adipose tissue, characterized by the presence of uncoupling protein (UCP) mRNA. In adult whole adipose tissues, beta 3-AR mRNA levels were high in deep deposits such as perirenal and omental, and lower in subcutaneous. In these deposits, UCP mRNA levels paralleled those of beta 3-AR. However, isolated omental and subcutaneous adipose cells, enriched in white adipocytes, expressed beta 3-AR but no UCP transcripts. beta 3-AR mRNA was highly expressed in gallbladder, and to a much lower extent in colon, independently of UCP mRNA. Quadriceps or abdominal muscles, heart, liver, lung, kidney, thyroid, and lymphocytes did not express intrinsic beta 3-AR mRNA. This study demonstrates that substantial amounts of brown adipocytes exist throughout life in adipose deposits, which are generally classified as white. These deposits are the main sites of beta 3-AR expression, which also occurs in gallbladder and colon. beta 3-AR may thus be involved in the control of lipid metabolism, possibly from fat assimilation in the digestive tract, to triglyceride storage and mobilization in adipose tissues.

subject areas

  • Adipose Tissue
  • Adult
  • Aged
  • Base Sequence
  • Blotting, Northern
  • Child
  • Child, Preschool
  • Female
  • Heart
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Oligonucleotides, Antisense
  • Organ Specificity
  • Polymerase Chain Reaction
  • RNA, Messenger
  • Receptors, Adrenergic, beta
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Research

keywords

  • ADIPOSE TISSUE
  • GALLBLADDER
  • OBESITY
  • POLYMERASE CHAIN REACTION
  • UNCOUPLING PROTEIN
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci116191

PubMed ID

  • 8380813
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Additional Document Info

start page

  • 344

end page

  • 349

volume

  • 91

issue

  • 1

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