Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Simultaneous deletion of myd88 and trif delays major histocompatibility and minor antigen mismatch allograft rejection

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • McKay, Dianne
  • Shigeoka, A.
  • Rubinstein, M.
  • Surh, Charles
  • Sprent, Jonathan

publication date

  • August 2006

journal

  • European Journal of Immunology  Journal

abstract

  • This study investigated whether ablation of all Toll-like receptor (TLR) signaling influenced skin allograft rejection across a complete donor/recipient mismatch of major histocompatibility and minor antigens. We predicted that defective TLR signaling would interfere with the activation of donor dendritic cells (DC) in vivo, by preventing DC activation in response to local environmental ("danger") signals. The ablation of TLR signals would therefore be associated with decreased activation of host T cells and decreased graft rejection. Using mice with deletions of the proximal TLR adapter proteins MyD88 or Trif, and those with simultaneous deletions of both MyD88 and Trif, we demonstrated that absence of both MyD88 and Trif adapter proteins prolonged skin graft survival, notably across a complete MHC and minor antigen barrier. Absence of MyD88 or Trif alone only had a modest effect on graft survival across even a minor MHC antigen difference. Prolonged survival of skin grafts from mice deficient in both MyD88 and Trif was associated with diminished migration of donor cells to draining lymph nodes and, subsequently, with delayed infiltration of host T cells into the grafted tissue.

subject areas

  • Adaptor Proteins, Signal Transducing
  • Adaptor Proteins, Vesicular Transport
  • Animals
  • Antigen-Presenting Cells
  • Antigens
  • Cell Movement
  • Cell Proliferation
  • Cells, Cultured
  • Gene Deletion
  • Graft Rejection
  • Histocompatibility
  • Lymph Nodes
  • Mice
  • Myeloid Differentiation Factor 88
  • Signal Transduction
  • Skin Transplantation
  • T-Lymphocytes
  • Toll-Like Receptors
  • Transplantation, Homologous
scroll to property group menus

Research

keywords

  • antigen-presenting cells
  • toll-like receptors
  • transplantation
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.200636249

PubMed ID

  • 16874736
scroll to property group menus

Additional Document Info

start page

  • 1994

end page

  • 2002

volume

  • 36

issue

  • 8

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support