Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Ferrari, C.
  • Penna, A.
  • Giuberti, T.
  • Tong, M. J.
  • Ribera, E.
  • Fiaccadori, F.
  • Chisari, Francis

publication date

  • September 1987

journal

  • Journal of Immunology  Journal

abstract

  • Hepatitis B core antigen (HBcAg)-specific T cell lines were established from hepatic lymphomononuclear cells derived from five patients with chronic active hepatitis B. No hepatitis B virus envelope antigen-specific cell lines were established. Proliferation in response to recombinant and native HBcAg, but not to native hepatitis B surface antigen containing the pre-S(2) region, confirmed the specificity of the five T cell lines. All cell lines represented mixed populations of CD4+ and CD8+ T cells. The CD4+ subset provided antigen-specific help to autologous B cells with respect to anti-HBc production and to CD8+ cells with regard to HBcAg-induced proliferation and suppressor activity. The CD8+ subset contained suppressor cells that selectively inhibited the proliferative response of autologous HBcAg-specific CD4+ cells without inhibiting CD4+ cells of unrelated specificity (tetanus toxoid). Moreover, the CD8+ cells were also capable of suppressing HBcAg-stimulated antibody to HBcAg production without showing inhibition of total immunoglobulin production stimulated by pokeweed mitogen. The cytotoxic potential of the T cell lines was established in a lectin-dependent cytotoxicity system; natural killer cytotoxicity was completely absent. Our data suggest that the lesional T cells present at the site of hepatocellular injury in chronic active hepatitis B are primarily HBcAg-specific lymphocytes of the helper and suppressor/cytotoxic phenotypes and that both are functionally competent.

subject areas

  • Antibody Formation
  • Antigen-Presenting Cells
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Surface
  • Capsid
  • Cytotoxicity, Immunologic
  • Female
  • HLA-D Antigens
  • Hepatitis B Antibodies
  • Hepatitis B Core Antigens
  • Hepatitis, Chronic
  • Humans
  • Immune Tolerance
  • Liver
  • Lymphocyte Activation
  • Male
  • Recombinant Proteins
  • T-Lymphocytes
  • T-Lymphocytes, Helper-Inducer
  • Viral Core Proteins
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0022-1767

PubMed ID

  • 2957446
scroll to property group menus

Additional Document Info

start page

  • 2050

end page

  • 2058

volume

  • 139

issue

  • 6

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support