Stereoselection in designed three-helix bundle metalloproteins

Academic Article

• Overview
• Research
• Identity
• Additional Document Info
• View All

Overview

authors

• Case, M. A.
• Ghadiri, M. Reza
• Mutz, M. W.
• McLendon, G. L.

publication date

• 1998

journal

• Chirality  Journal

abstract

• The stereochemical consequences of the metal-ion assisted self-assembly of parallel three-helix peptide bundles are investigated. Chiral induction in the self-assembly of systems containing extensive protein secondary structure is compared with the racemic synthesis of short metallopeptides. Isolation and characterization of the individual stereoisomers of an exchange-inert metalloprotein provide structural insights into analogous exchange-labile systems.

subject areas

• Circular Dichroism
• Entropy
• Iron
• Magnetic Resonance Spectroscopy
• Metalloproteins
• Peptides
• Protein Conformation
• Ruthenium
• Stereoisomerism

Research

keywords

• de novo design
• diastereoselection
• metalloproteins
• self-assembly

Identity

International Standard Serial Number (ISSN)

• 0899-0042

Digital Object Identifier (DOI)

• 10.1002/(sici)1520-636x(1998)10:1/2<35::aid-chir7>3.0.co;2-o

PubMed ID

• 9470207

Additional Document Info

start page

• 35

end page

• 40

volume

• 10

issue

• 1-2