Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Structural markers on core protein p-30 of murine leukemia-virus - functional correlation with fv-1 tropism

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Gautsch, J. W.
  • Elder, John
  • Schindler, J.
  • Jensen, F. C.
  • Lerner, Richard

publication date

  • 1978

journal

  • Proceedings of the National Academy of Sciences of the United States of America  Journal

abstract

  • Tryptic peptide maps from more than 50 isolates of murine leukemia virus (MuLV) have shown that, in general, the structure of core protein p30 is highly conserved. However, a structurally variable region of p30 has been identified that is functionally associated with Fv-1 tropism. On the basis of this structural variability, MuLV strains can be classified as B-tropic, N-tropic, xenotropic, and/or as being derived from wild mice. Certain xenotropic viruses have a p30 like that of B-tropic MuLV and presumably would be subject to restriction in cells containing an Fv-In allele. Other p30 structural markers serve to distinguish the exogenous Friend, Moloney, and Rauscher viruses from endogenous MuLV. Furthermore, some MuLV strains have structural differences in their p30s that are useful as strain-specific markers. Finally, a possible sarcoma-associated alteration in the structure of p30 has been noted in the ml clone of Moloney murine sarcoma virus.

subject areas

  • Amino Acid Sequence
  • Animals
  • Leukemia Virus, Murine
  • Mice
  • Mice, Inbred Strains
  • Peptide Fragments
  • Sarcoma Viruses, Murine
  • Species Specificity
  • Viral Proteins
  • Virus Replication
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.75.9.4170

PubMed ID

  • 212738
scroll to property group menus

Additional Document Info

start page

  • 4170

end page

  • 4174

volume

  • 75

issue

  • 9

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support