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Brain-specific genes have identifier sequences in their introns

Academic Article
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Overview

authors

  • Bloom, Floyd
  • Lai, C.
  • Lerner, Richard
  • Milner, R, J.
  • Sutcliffe, J. Gregor

publication date

  • 1984

journal

  • Proceedings of the National Academy of Sciences of the United States of America-Biological Sciences  Journal

abstract

  • The 82-nucleotide identifier (ID) sequence is present in the rat genome in 1-1.5 X 10(5) copies and in cDNA clones of precursors of brain-specific mRNAs. One brain-specific gene contains more than one ID sequence in its introns. There is an excess of ID sequences to brain genes, and some ID sequences appear to have been inserted as mobile elements into other genetic locations. Therefore, brain genes contain ID sequences in their introns, but not all ID sequences are located in brain gene introns. A brain ID consensus sequence has been obtained by comparing 8 ID nucleotide sequences.

subject areas

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain
  • Cloning, Molecular
  • DNA
  • Genes
  • Nerve Tissue Proteins
  • Nucleic Acid Hybridization
  • Rats
  • Repetitive Sequences, Nucleic Acid
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Identity

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.81.3.713

PubMed ID

  • 6583673
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Additional Document Info

start page

  • 713

end page

  • 717

volume

  • 81

issue

  • 3

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