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Leukocytes and organ-nonspecific autoantibodies in schizophrenics and their siblings: Markers of vulnerability or disease?

Academic Article
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Overview

authors

  • Zorrilla, Eric
  • Cannon, T. D.
  • Gur, R. E.
  • Kessler, J.

publication date

  • November 1996

journal

  • Biological Psychiatry  Journal

abstract

  • To determine whether leukocyte counts and organ-nonspecific autoantibodies mark familial vulnerability for schizophrenia and/or the disease itself, we examined 92 patients with schizophrenia and 94 unrelated, demographically balanced, healthy individuals. In addition, for 19 of the probands, one of their nonschizophrenia, full siblings also was recruited. At the time of the blood draw, most probands (87%) had been free of medications for a minimum of 2 weeks and about half were neuroleptic-naive, first-episode patients. Results indicate that a relative lymphopenia in the context of a relative granulocytosis appears to mark familial vulnerability for schizophrenia, whereas an absolute monocytosis appears to mark spectrum manifestations of the clinical phenotype. The former observation is consistent with the hypothesis that the etiology of schizophrenia is immunologically mediated, whereas the latter is consistent with emerging evidence that an inflammatory process is associated with the expression of the disorder. Neither antinuclear antibody nor rheumatoid factor emerged as liability or disease markers.

subject areas

  • Adult
  • Antibody Specificity
  • Autoantibodies
  • Autoimmune Diseases
  • Female
  • Granulocytes
  • Humans
  • Leukocyte Count
  • Lymphopenia
  • Male
  • Middle Aged
  • Phenotype
  • Schizophrenia
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Research

keywords

  • autoantibodies
  • family study
  • granulocytes
  • leukocytes
  • lymphocytes
  • monocytes
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Identity

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/0006-3223(95)00598-6

PubMed ID

  • 8896768
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Additional Document Info

start page

  • 825

end page

  • 833

volume

  • 40

issue

  • 9

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