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Cellular and molecular mechanisms of memory: The ltp connection

Academic Article
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Overview

authors

  • Miller, S.
  • Mayford, Mark

publication date

  • 1999

journal

  • Current Opinion in Genetics & Development  Journal

abstract

  • Studies of the cellular and molecular mechanisms of memory formation have focused on the role of long-lasting forms of synaptic plasticity such as long-term potentiation (LTP). A combination of genetic, electrophysiological and behavioral techniques have been used to examine the possibility that LTP is a cellular mechanism of memory storage in the mammalian brain. Although a definitive answer remains elusive, it is clear that in many cases manipulations that alter LTP alter memory, and training regimens that produce memory can produce LTP-like potentiation of synaptic transmission.

subject areas

  • Animals
  • Humans
  • Learning
  • Long-Term Potentiation
  • Memory
  • Mice
  • Mice, Mutant Strains
  • Receptors, N-Methyl-D-Aspartate
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Identity

International Standard Serial Number (ISSN)

  • 0959-437X

Digital Object Identifier (DOI)

  • 10.1016/s0959-437x(99)80050-1

PubMed ID

  • 10377283
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Additional Document Info

start page

  • 333

end page

  • 337

volume

  • 9

issue

  • 3

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