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Sequence characterization of human Borna disease virus

Academic Article
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Overview

authors

  • de la Torre, Juan
  • Bode, L.
  • Durrwald, R.
  • Cubitt, B.
  • Ludwig, H.

publication date

  • September 1996

journal

  • Virus Research  Journal

abstract

  • Borna disease virus (BDV) causes a central nervous system disease in several vertebrate animal species, which is manifest by behavioral abnormalities. Seroepidemiologic data suggest that BDV might infect humans, possibly being associated with certain mental disorders. This is further supported by the detection of both BDV-specific antigens and RNA sequences in peripheral blood mononuclear cells (PBMCs) of psychiatric patients. For the first time the sequence characterization of human BDV is documented here. BDV was recovered by co-cultivation techniques from the PBMCs of three hospitalized psychiatric patients. BDV was unequivocally identified based on sequence identification of BDV open reading frames (ORFs) p24, p16 and p56, as well as of the predicted catalytic domain of the BDV L polymerase. Each human BDV isolate had an unique sequence, but they displayed a high degree of sequence conservation with respect of BDV isolates from naturally infected animals of different species.

subject areas

  • Adult
  • Base Sequence
  • Borna Disease
  • Borna disease virus
  • DNA, Viral
  • Female
  • Gene Expression
  • Humans
  • Leukocytes, Mononuclear
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • RNA, Viral
  • Sequence Homology, Nucleic Acid
  • Viral Proteins
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Research

keywords

  • human Borna disease virus
  • peripheral blood mononuclear cells
  • three BDV genes
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Identity

International Standard Serial Number (ISSN)

  • 0168-1702

Digital Object Identifier (DOI)

  • 10.1016/0168-1702(96)01338-x

PubMed ID

  • 8873411
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Additional Document Info

start page

  • 33

end page

  • 44

volume

  • 44

issue

  • 1

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