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Solution NMR structure determination of proteins revisited

Academic Article
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Overview

authors

  • Billeter, M.
  • Wagner, G.
  • Wuthrich, Kurt

publication date

  • 2008

journal

  • Journal of Biomolecular NMR  Journal

abstract

  • This 'Perspective' bears on the present state of protein structure determination by NMR in solution. The focus is on a comparison of the infrastructure available for NMR structure determination when compared to protein crystal structure determination by X-ray diffraction. The main conclusion emerges that the unique potential of NMR to generate high resolution data also on dynamics, interactions and conformational equilibria has contributed to a lack of standard procedures for structure determination which would be readily amenable to improved efficiency by automation. To spark renewed discussion on the topic of NMR structure determination of proteins, procedural steps with high potential for improvement are identified.

subject areas

  • Biochemical Processes
  • Nuclear Magnetic Resonance, Biomolecular
  • Protein Conformation
  • Proteins
  • X-Ray Diffraction
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Research

keywords

  • Automation
  • NMR structure determination of proteins
  • Protein biochemistry
  • Structural biology
  • Structural genomics
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Identity

PubMed Central ID

  • PMC2748914

International Standard Serial Number (ISSN)

  • 0925-2738

Digital Object Identifier (DOI)

  • 10.1007/s10858-008-9277-8

PubMed ID

  • 18827972
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Additional Document Info

start page

  • 155

end page

  • 158

volume

  • 42

issue

  • 3

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