recent publications

• academic article

  • Leclerc, E., Serban, H., Prusiner, S. B., Burton, D. R., Williamson, R. A. Copper induces conformational changes in the n-terminal part of cell-surface prpc Archives of Virology  2006 151:2103-2109  DOI:10.1007/s00705-006-0804-1  PMID:16791441
  • Peters, P. J., Mironov, A., Peretz, D., van Donselaar, E., Leclerc, E., Erpel, S., DeArmond, S. J., Burton, D. R., Williamson, R. A., Vey, M., Prusiner, S. B. Trafficking of prion proteins through a caveolae-mediated endosomal pathway Journal of Cell Biology  2003 162:703-717  DOI:10.1083/jcb.200304140  PMID:12925711  PMCID:PMC2173792
  • Leclerc, E., Peretz, D., Ball, H., Solforosi, L., Legname, G., Safar, J., Serban, A., Prusiner, S. B., Burton, D. R., Williamson, R. A. Conformation of prpc on the cell surface as probed by antibodies Journal of Molecular Biology  2003 326:475-483  DOI:10.1016/s0022-2836(02)01365-7  PMID:12559915
  • Safar, J. G., Scott, M., Monaghan, J., Deering, C., Didorenko, S., Vergara, J., Ball, H., Legname, G., Leclerc, E., Solforosi, L., Serban, H., Groth, D., et al. Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice Nature Biotechnology  2002 20:1147-1150  DOI:10.1038/nbt748  PMID:12389035
  • Peretz, D., Williamson, R. A., Kaneko, K., Vergara, J., Leclerc, E., Schmitt-Ulms, G., Mehlhorn, I. R., Legname, G., Wormald, M. R., Rudd, P. M., Dwek, R. A., Burton, D. R., et al. Antibodies inhibit prion propagation and clear cell cultures of prion infectivity Nature  2001 412:739-743  DOI:10.1038/35089090  PMID:11507642
  • Leclerc, E., Peretz, D., Ball, H., Sakurai, H., Legname, G., Serban, A., Prusiner, S. B., Burton, D. R., Williamson, R. A. Immobilized prion protein undergoes spontaneous rearrangement to a conformation having features in common with the infectious form EMBO Journal  2001 20:1547-1554  DOI:10.1093/emboj/20.7.1547  PMID:11285219  PMCID:PMC145482
  • Williamson, R. A., Burgoon, M. P., Owens, G. P., Ghausi, O., Leclerc, E., Firme, L., Carlson, S., Corboy, J., Parren, Pwhi, Sanna, P. P., Gilden, D. H., Burton, D. R. Anti-DNA antibodies are a major component of the intrathecal B cell response in multiple sclerosis Proceedings of the National Academy of Sciences of the United States of America  2001 98:1793-1798  DOI:10.1073/pnas.031567598  PMID:11172030  PMCID:PMC29336