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Dopamine activation of endogenous cannabinoid signaling in dorsal striatum

Academic Article
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Overview

authors

  • Giuffrida, A.
  • Parsons, Loren (Larry)
  • Kerr, T. M.
  • de Fonseca, F. R.
  • Navarro, M.
  • Piomelli, D.

publication date

  • April 1999

journal

  • Nature Neuroscience  Journal

abstract

  • We measured endogenous cannabinoid release in dorsal striatum of freely moving rats by microdialysis and gas chromatography/mass spectrometry. Neural activity stimulated the release of anandamide, but not of other endogenous cannabinoids such as 2-arachidonylglycerol. Moreover, anandamide release was increased eightfold over baseline after local administration of the D2-like (D2, D3, D4) dopamine receptor agonist quinpirole, a response that was prevented by the D2-like receptor antagonist raclopride. Administration of the D1-like (D1, D5) receptor agonist SKF38393 had no such effect. These results suggest that functional interactions between endocannabinoid and dopaminergic systems may contribute to striatal signaling. In agreement with this hypothesis, pretreatment with the cannabinoid antagonist SR141716A enhanced the stimulation of motor behavior elicited by systemic administration of quinpirole. The endocannabinoid system therefore may act as an inhibitory feedback mechanism countering dopamine-induced facilitation of motor activity.

subject areas

  • 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
  • Animals
  • Arachidonic Acids
  • Calcium
  • Cannabinoid Receptor Modulators
  • Corpus Striatum
  • Dopamine
  • Dopamine Agonists
  • Dopamine Antagonists
  • Endocannabinoids
  • Ethanolamines
  • Gas Chromatography-Mass Spectrometry
  • Glycerides
  • Hyperkinesis
  • Male
  • Microdialysis
  • Motor Activity
  • Oleic Acids
  • Palmitic Acids
  • Piperidines
  • Polyunsaturated Alkamides
  • Potassium
  • Pyrazoles
  • Quinpirole
  • Raclopride
  • Rats
  • Rats, Wistar
  • Receptors, Cannabinoid
  • Receptors, Dopamine D2
  • Receptors, Drug
  • Salicylamides
  • Signal Transduction
  • Single-Blind Method
  • Sodium
  • Tetrodotoxin
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Identity

International Standard Serial Number (ISSN)

  • 1097-6256

Digital Object Identifier (DOI)

  • 10.1038/7268

PubMed ID

  • 10204543
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Additional Document Info

start page

  • 358

end page

  • 363

volume

  • 2

issue

  • 4

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