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Investigating highly crosslinked macroporous resins for solid-phase synthesis

Academic Article
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Overview

authors

  • Hori, M.
  • Gravert, D. J.
  • Wentworth Jr., Paul
  • Janda, Kim

publication date

  • September 1998

journal

  • Bioorganic & Medicinal Chemistry Letters  Journal

abstract

  • The washing efficiencies of a chromophore and the reaction rates of a classical esterification reaction are improved with macroporous resins (MRs) relative to a classical Merrifield resin. Furthermore, Wacker-oxidation of a MR bound alkene yielded the expected methylketone product whereas an alkene bound to a low-crosslinked Merrifield resin gave no product, a function of the relative permeability of each of these resins to the aqueous solvent conditions employed.

subject areas

  • Cross-Linking Reagents
  • Drug Design
  • Esters
  • Ketones
  • Kinetics
  • Molecular Conformation
  • Molecular Structure
  • Resins, Synthetic
  • Structure-Activity Relationship
  • Surface Properties
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Identity

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(98)00427-2

PubMed ID

  • 9873542
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Additional Document Info

start page

  • 2363

end page

  • 2368

volume

  • 8

issue

  • 17

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