Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form

Effect of immune priming on borna disease

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Lewis, A. J.
  • Whitton, J. Lindsay
  • Hatalski, C. G.
  • Weissenbock, H.
  • Lipkin, W. I.

publication date

  • March 1999

journal

  • Journal of Virology  Journal

abstract

  • Borna disease virus (BDV) is a neurotropic virus with a broad host and geographic range. Lewis rats were immunized against BDV with a recombinant vaccinia virus expressing the BDV nucleoprotein and were later infected with BDV to evaluate protection against Borna disease (BD). Relative to animals that were not immunized, immunized animals had a decreased viral burden after challenge with infectious virus, more marked inflammation, and aggravated clinical disease. These data suggest that a more robust immune response in Borna disease can reduce viral load at the expense of increased morbidity.

subject areas

  • Animals
  • Antibodies, Viral
  • Borna Disease
  • HeLa Cells
  • Humans
  • Immunization
  • Male
  • Nucleoproteins
  • RNA, Viral
  • Rats
  • Rats, Inbred Lew
  • Viral Vaccines
scroll to property group menus

Identity

PubMed Central ID

  • PMC104502

International Standard Serial Number (ISSN)

  • 0022-538X

PubMed ID

  • 9971840
scroll to property group menus

Additional Document Info

start page

  • 2541

end page

  • 2546

volume

  • 73

issue

  • 3

©2021 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support