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Drosophila homer is required in a small set of neurons including the ellipsoid body for normal ethanol sensitivity and tolerance

Academic Article
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Overview

authors

  • Urizar, N. L.
  • Yang, Z. Y.
  • Edenberg, H. J.
  • Davis, Ronald

publication date

  • April 2007

journal

  • Journal of Neuroscience  Journal

abstract

  • The molecular mechanisms occurring in the nervous system that underlie behavioral responses to ethanol remain poorly understood. Here, we report that molecular requirements for two of these responses, initial sensitivity and the development of rapid tolerance, comap to the same small set of neurons. We show that null homer mutant flies exhibit both increased sensitivity to the sedative effects of ethanol and failure to develop normal levels of rapid tolerance. Both the sensitivity and rapid tolerance phenotypes of the homer mutants are rescued by the expression of wild-type homer in a subset of neurons that include the ellipsoid body. Thus, some of the molecular- and systems-level requirements for these two behavioral responses to ethanol are identical.

subject areas

  • Animals
  • Animals, Genetically Modified
  • Brain
  • Carrier Proteins
  • Central Nervous System Depressants
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Drosophila melanogaster
  • Drug Resistance
  • Drug Tolerance
  • Ethanol
  • Male
  • Neurons
  • Oligonucleotide Array Sequence Analysis
  • Phenotype
  • Saccharomyces cerevisiae Proteins
  • Transcription Factors
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Research

keywords

  • Drosophila
  • ellipsoid body
  • ethanol
  • homer
  • sensitivity
  • tolerance
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Identity

International Standard Serial Number (ISSN)

  • 0270-6474

Digital Object Identifier (DOI)

  • 10.1523/jneurosci.0305-07.2007

PubMed ID

  • 17460067
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Additional Document Info

start page

  • 4541

end page

  • 4551

volume

  • 27

issue

  • 17

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