recent publications
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academic article
- Gu, Y. H., Kanazawa, M., Hung, S. Y., Wang, X., Fukuda, S., Koziol, J. A., del Zoppo, G. J. Cathepsin L acutely alters microvessel integrity within the neurovascular unit during focal cerebral ischemia Journal of Cerebral Blood Flow and Metabolism 2015 35:1888-1900 DOI:10.1038/jcbfm.2015.170 PMID:26198177 PMCID:PMC4635247
- del Zoppo, G. J., Frankowski, H., Gu, Y. H., Osada, T., Kanazawa, M., Milner, R., Wang, X. Y., Hosomi, N., Mabuchi, T., Koziol, J. A. Microglial cell activation is a source of metalloproteinase generation during hemorrhagic transformation Journal of Cerebral Blood Flow and Metabolism 2012 32:919-932 DOI:10.1038/jcbfm.2012.11 PMID:22354151 PMCID:PMC3345906
- Osada, T., Gu, Y. H., Kanazawa, M., Tsubota, Y., Hawkins, B. T., Spatz, M., Milner, R., del Zoppo, G. J. Interendothelial claudin-5 expression depends on cerebral endothelial cell-matrix adhesion by beta(1)-integrins Journal of Cerebral Blood Flow and Metabolism 2011 31:1972-1985 DOI:10.1038/jcbfm.2011.99 PMID:21772312 PMCID:PMC3208159
- Milner, R., Hung, S., Erokwu, B., Dore-Duffy, P., LaManna, J. C., del Zoppo, G. J. Increased expression of fibronectin and the alpha 5 beta 1 integrin in angiogenic cerebral blood vessels of mice subject to hypobaric hypoxia Molecular and Cellular Neuroscience 2008 38:43-52 DOI:10.1016/j.mcn.2008.01.013 PMID:18343155 PMCID:PMC2588547
- Milner, R., Hung, S., Wang, X., Berg, G. I., Spatz, M., del Zoppo, G. J. Responses of endothelial cell and astrocyte matrix-integrin receptors to ischemia mimic those observed in the neurovascular unit Stroke 2008 39:191-197 DOI:10.1161/strokeaha.107.486134 PMID:18032737 PMCID:PMC2588548
- Milner, R., Hung, S., Wang, X., Spatz, M., del Zoppo, G. J. The rapid decrease in astrocyte-associated dystroglycan expression by focal cerebral ischemia is protease-dependent Journal of Cerebral Blood Flow and Metabolism 2008 28:812-823 DOI:10.1038/sj.jcbfm.9600585 PMID:18030304 PMCID:PMC2588545
- Milner, R., Crocker, S. J., Hung, S., Wang, X. Y., Frausto, R. F., del Zoppo, G. J. Fibronectin- and vitronectin-induced microglial activation and matrix metalloproteinase-9 expression is mediated by integrins alpha(5)beta(1) and alpha(v)beta(5) Journal of Immunology 2007 178:8158-8167 PMID:17548654
- del Zoppo, G. J., Milner, R., Mabuchi, T., Hung, S., Wang, X. Y., Berg, G. I., Koziol, J. A. Microglial activation and matrix protease generation during focal cerebral ischemia Stroke 2007 38:646-651 DOI:10.1161/01.STR.0000254477.34231.cb PMID:17261708
- del Zoppo, G. J., Milner, R. Integrin-matrix interactions in the cerebral microvasculature Arteriosclerosis, Thrombosis, and Vascular Biology 2006 26:1966-1975 DOI:10.1161/01.ATV.0000232525.65682.a2 PMID:16778120
- del Zoppo, G. J., Milner, R., Mabuchi, T., Hung, S., Wang, X., Koziol, J. A. Vascular matrix adhesion and the blood-brain barrier Biochemical Society Transactions 2006 34:1261-1266 PMID:17073798
- Mabuchi, T., Lucero, J., Feng, A., Koziol, J. A., del Zoppo, G. J. Focal cerebral ischemia preferentially affects neurons distant from their neighboring microvessels Journal of Cerebral Blood Flow and Metabolism 2005 25:257-266 DOI:10.1038/sj.jcbfm.9600027 PMID:15678127
- Fukuda, S., Fini, C. A., Mabuchi, T., Koziol, J. A., Eggleston, L. L., del Zoppo, G. J. Focal cerebral ischemia induces active proteases that degrade microvascular matrix Stroke 2004 35:998-1004 DOI:10.1161/01.str.0000119383.76447.05 PMID:15001799
- Hosomi, N., Lucero, J., Heo, J. H., Koziol, J. A., Copeland, B. R., del Zoppo, G. J. Rapid differential endogenous plasminogen activator expression after acute middle cerebral artery occlusion Stroke 2001 32:1341-1348 PMID:11387497
- Tagaya, M., Haring, H. P., Stuiver, I., Wagner, S., Abumiya, T., Lucero, J., Lee, P., Copeland, B. R., Seiffert, D., del Zoppo, G. J. Rapid loss of microvascular integrin expression during focal brain ischemia reflects neuron injury Journal of Cerebral Blood Flow and Metabolism 2001 21:835-846 PMID:11435796
- Abumiya, T., Fitridge, R., Mazur, C., Copeland, B. R., Koziol, J. A., Tschopp, J. F., Pierschbacher, M. D., del Zoppo, G. J. Integrin alpha(iib)beta(3) inhibitor preserves microvascular patency in experimental acute focal cerebral ischemia Stroke 2000 31:1402-1409 PMID:10835463
- Abumiya, T., Lucero, J., Heo, J. H., Tagaya, M., Koziol, J. A., Copeland, B. R., del Zoppo, G. J. Activated microvessels express vascular endothelial growth factor and integrin alpha(v)beta(3) during focal cerebral ischemia Journal of Cerebral Blood Flow and Metabolism 1999 19:1038-1050 PMID:10478656
- Heo, J. H., Lucero, J., Abumiya, T., Koziol, J. A., Copeland, B. R., del Zoppo, G. J. Matrix metalloproteinases increase very early during experimental focal cerebral ischemia Journal of Cerebral Blood Flow and Metabolism 1999 19:624-633 DOI:10.1097/00004647-199906000-00005 PMID:10366192