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Mice deficient in stem cell antigen-1 (sca1, ly-6a/e) develop normal primary and memory cd4(+) and cd8(+) t-cell responses to virus infection

Academic Article
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Overview

authors

  • Whitmire, Jason
  • Eam, B.
  • Whitton, J. Lindsay

publication date

  • June 2009

journal

  • European Journal of Immunology  Journal

abstract

  • Stem cell antigen-1 (Sca1, Ly-6A/E) is a well-established marker of murine hematopoietic stem cells, and also is expressed on memory T cells. It has been suggested that the functional maintenance of T-cell memory requires the expression of Sca1 on a specialized population of memory T cells termed "memory stem cells". Here, we evaluate the requirement for Sca1 in the primary T-cell response to virus infection, and in the establishment and maintenance of T-cell memory. We find that Sca1 expression increases on almost all CD4(+) and CD8(+) T cells during virus infection, and remains high on virus-specific memory cells. However, Sca1-deficient (Sca1KO) mice generate normal primary T-cell responses to infection; the kinetics, the immunodominance hierarchy, and the absolute numbers of CD4(+) and CD8(+) T cells are essentially indistinguishable from those observed in WT mice. Furthermore, by several criteria, primary and memory T cells in Sca1-deficient mice are phenotypically and functionally normal. These data indicate that Sca1, although perhaps a useful marker of virus-specific memory T cells, is not required for the regulation of T-cell quantity or quality, or for the development of a competent pool of memory cells.

subject areas

  • Animals
  • Antigens, CD44
  • Antigens, Ly
  • Arenaviridae Infections
  • CD4-Positive T-Lymphocytes
  • CD8-Positive T-Lymphocytes
  • Cell Count
  • Immunity, Cellular
  • Immunologic Memory
  • Interferon-gamma
  • Interleukin-2
  • Kinetics
  • Lymphocytic choriomeningitis virus
  • Membrane Proteins
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Mice, Transgenic
  • Receptors, Interferon
  • Spleen
  • T-Lymphocyte Subsets
  • T-Lymphocytes, Cytotoxic
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Research

keywords

  • Cellular activation
  • Memory cells
  • T cells
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Identity

PubMed Central ID

  • PMC2757104

International Standard Serial Number (ISSN)

  • 0014-2980

Digital Object Identifier (DOI)

  • 10.1002/eji.200838959

PubMed ID

  • 19384870
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Additional Document Info

start page

  • 1494

end page

  • 1504

volume

  • 39

issue

  • 6

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