Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Circulating tumor cells from well-differentiated lung adenocarcinoma retain cytomorphologic features of primary tumor type

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

related to degree

  • Marrinucci, Dena, Ph.D. in Biology, Scripps Research 2004 - 2009

authors

  • Marrinucci, Dena
  • Bethel, Kelly
  • Luttgen, M.
  • Bruce, R. H.
  • Nieva, Jorge Javier
  • Kuhn, Peter

publication date

  • September 2009

journal

  • Archives of Pathology & Laboratory Medicine  Journal

abstract

  • The detailed cytomorphologic appearance of circulating tumor cells (CTCs) in cancer patients is not well described, despite publication of multiple methods for enumerating these cells. In this case study, we present the cytomorphology of CTCs obtained from the blood of a woman with stage IIIB well-differentiated lung adenocarcinoma. Four years after she was diagnosed with her disease, 67 CTCs were identified in a blood sample using an immunofluorescent staining protocol and then subsequently stained with Wright-Giemsa. The cytomorphology of the CTCs was compared with the original tissue biopsy from 4 years prior. We found that CTCs and cells from the original biopsy had strikingly similar morphologic features, including large size in comparison to white blood cells and low nuclear to cytoplasmic ratios with voluminous cytoplasm. Careful cytomorphologic evaluation of CTCs will provide insights about the metastatic significance of these cells, which could yield widespread implications for the diagnosis, treatment, and management of cancer.

subject areas

  • Adenocarcinoma
  • Cell Count
  • Cell Survival
  • Combined Modality Therapy
  • Female
  • Humans
  • Lung Neoplasms
  • Middle Aged
  • Neoplasm Staging
  • Neoplastic Cells, Circulating
  • Pathology, Surgical
scroll to property group menus

Identity

PubMed Central ID

  • PMC4422331

International Standard Serial Number (ISSN)

  • 0003-9985

Digital Object Identifier (DOI)

  • 10.1043/1543-2165-133.9.1468

PubMed ID

  • 19722757
scroll to property group menus

Additional Document Info

start page

  • 1468

end page

  • 1471

volume

  • 133

issue

  • 9

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support