recent publications

• academic article

  • Oshima, T., Yamanaka, I., Kumar, A., Yamaguchi, J., Nishiwaki-Ohkawa, T., Muto, K., Kawamura, R., Hirota, T., Yagita, K., Irle, S., Kay, S. A., Yoshimura, T., et al. C-H activation generates period-shortening molecules that target cryptochrome in the mammalian circadian clock Angewandte Chemie-International Edition  2015 54:7193-7197  DOI:10.1002/anie.201502942  PMID:25960183
  • Lee, J. W., Hirota, T., Kumar, A., Kim, N. J., Irle, S., Kay, S. A. Development of small-molecule cryptochrome stabilizer derivatives as modulators of the circadian clock ChemMedChem  2015 10:1489-1497  DOI:10.1002/cmdc.201500260  PMID:26174033  PMCID:PMC4576822
  • Kumar, A., Punta, M., Axelrod, H. L., Das, D., Farr, C. L., Grant, J. C., Chiu, H. J., Miller, M. D., Coggill, P. C., Klock, H. E., Elsliger, M. A., Deacon, A. M., et al. Crystal structures of three representatives of a new Pfam family PF14869 (DUF4488) suggest they function in sugar binding/uptake Protein Science  2014 23:1380-1391  DOI:10.1002/pro.2522  PMID:25044324  PMCID:PMC4287006
  • Kumar, A., Parkesh, R., Sznajder, L. J., Childs-Disney, J. L., Sobczak, K., Disney, M. D. Chemical correction of pre-mRNA splicing defects associated with sequestration of muscleblind-like 1 protein by expanded r(CAG)-containing transcripts ACS Chemical Biology  2012 7:496-505  DOI:10.1021/cb200413a  PMID:22252896  PMCID:PMC3306454
  • Parkesh, R., Childs-Disney, J. L., Nakamori, M., Kumar, A., Wang, E., Wang, T., Hoskins, J., Tran, T., Housman, D., Thornton, C. A., Disney, M. D. Design of a bioactive small molecule that targets the myotonic dystrophy type 1 RNA via an RNA motif-ligand database and chemical similarity searching Journal of the American Chemical Society  2012 134:4731-4742  DOI:10.1021/ja210088v  PMID:22300544  PMCID:PMC3306011
  • Klionsky, D. J., Abdalla, F. C., Abeliovich, H., Abraham, R. T., Acevedo-Arozena, A., Adeli, K., Agholme, L., Agnello, M., Agostinis, P., Aguirre-Ghiso, J. A., Ahn, H. J., Ait-Mohamed, O., et al. Guidelines for the use and interpretation of assays for monitoring autophagy Autophagy  2012 8:445-544  DOI:10.4161/auto.19496  PMID:22966490  PMCID:PMC3404883
  • Kumar, A., Mocklinghoff, S., Yumoto, F., Jaroszewski, L., Farr, C. L., Grzechnik, A., Nguyen, P., Weichenberger, C. X., Chiu, H. J., Klock, H. E., Elsliger, M. A., Deacon, A. M., et al. Structure of a novel winged-helix like domain from human NFRKB protein PLoS One  2012 7:e43761  DOI:10.1371/journal.pone.0043761  PMID:22984442  PMCID:PMC3439487
  • Kumar, A., Fang, P. F., Park, H., Guo, M., Nettles, K. W., Disney, M. D. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome ChemBioChem  2011 12:2140-2142  DOI:10.1002/cbic.201100337  PMID:21766409  PMCID:PMC3379549
  • Kumar, A., Park, H., Fang, P. F., Parkesh, R., Guo, M., Nettles, K. W., Disney, M. D. Myotonic dystrophy type 1 RNA crystal structures reveal heterogeneous 1 x 1 nucleotide UU internal loop conformations Biochemistry  2011 50:9928-9935  DOI:10.1021/bi2013068  PMID:21988728  PMCID:PMC3218087
  • Xu, Q. P., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Cai, X. H., Carlton, D., Chen, C., Chiu, H. J., Chiu, M., Clayton, T., Das, D., et al. A conserved fold for fimbrial components revealed by the crystal structure of a putative fimbrial assembly protein (BT1062) from bacteroides thetaiotaomicron at 2.2 A resolution Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1281-1286  DOI:10.1107/s1744309110006548  PMID:20944223  PMCID:PMC2954217
  • Xu, Q., Bateman, A., Finn, R. D., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Carlton, D., Chen, C., Chiu, H. J., Chiu, M., Clayton, T., et al. Bacterial pleckstrin homology domains: A prokaryotic origin for the PH domain Journal of Molecular Biology  2010 396:31-46  DOI:10.1016/j.jmb.2009.11.006  PMID:19913036  PMCID:PMC2817789
  • Axelrod, H. L., Kozbial, P., McMullan, D., Krishna, S. S., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Carlton, D., Caruthers, J., Chiu, H. J., Clayton, T., et al. Conformational changes associated with the binding of zinc acetate at the putative active site of XcTcmJ, a cupin from Xanthomonas Campestris pv. Campestris Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1347-1353  DOI:10.1107/s1744309109021988  PMID:20944231  PMCID:PMC2954225
  • Das, D., Moiani, D., Axelrod, H. L., Miller, M. D., McMullan, D., Jin, K. K., Abdubek, P., Astakhova, T., Burra, P., Carlton, D., Chiu, H. J., Clayton, T., et al. Crystal structure of the first eubacterial Mre11 nuclease reveals novel features that may discriminate substrates during DNA repair Journal of Molecular Biology  2010 397:647-663  DOI:10.1016/j.jmb.2010.01.049  PMID:20122942  PMCID:PMC2839085
  • Kumar, A., Chiu, H. J., Axelrod, H. L., Morse, A., Elsliger, M. A., Wilson, I. A., Deacon, A. Ligands in psi structures Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1309-1316  DOI:10.1107/s1744309110008092  PMID:20944227  PMCID:PMC2954221
  • Kumar, A., Lomize, A., Jin, K. K., Carlton, D., Miller, M. D., Jaroszewski, L., Abdubek, P., Astakhova, T., Axelrod, H. L., Chiu, H. J., Clayton, T., Das, D., et al. Open and closed conformations of two SpoiiAA-like proteins (YP_749275.1 and YP_001095227.1) provide insights into membrane association and ligand binding Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1245-1253  DOI:10.1107/s1744309109042481  PMID:20944218  PMCID:PMC2954212
  • Bakolitsa, C., Xu, Q. P., Rife, C. L., Abdubek, P., Astakhova, T., Axelrod, H. L., Carlton, D., Chen, C., Chiu, H. J., Clayton, T., Das, D., Deller, M. C., et al. Structure of BT_3984, a member of the SusD/RagB family of nutrient-binding molecules Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1274-1280  DOI:10.1107/s1744309110032999  PMID:20944222  PMCID:PMC2954216
  • Yeh, A. P., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Cai, X. H., Carlton, D., Chen, C., Chiu, H. J., Chiu, M., Clayton, T., Das, D., et al. Structure of Bacteroides thetaiotaomicron BT2081 at 2.05 A resolution: The first structural representative of a new protein family that may play a role in carbohydrate metabolism Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1287-1296  DOI:10.1107/s1744309110028228  PMID:20944224  PMCID:PMC2954218
  • Bakolitsa, C., Kumar, A., Carlton, D., Miller, M. D., Krishna, S. S., Abdubek, P., Astakhova, T., Axelrod, H. L., Chiu, H. J., Clayton, T., Deller, M. C., Duan, L. A., et al. Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1205-1210  DOI:10.1107/s1744309109023689  PMID:20944212  PMCID:PMC2954206
  • Xu, Q. P., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Cai, X. H., Carlton, D., Chen, C., Chiu, H. J., Clayton, T., Das, D., Deller, M. C., et al. Structure of a membrane-attack complex/perforin (MACPF) family protein from the human gut symbiont Bacteroides thetaiotaomicron Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1297-1305  DOI:10.1107/s1744309110023055  PMID:20944225  PMCID:PMC2954219
  • Han, G. W., Elsliger, M. A., Yeates, T. O., Xu, Q. P., Murzin, A. G., Krishna, S. S., Jaroszewski, L., Abdubek, P., Astakhova, T., Axelrod, H. L., Carlton, D., Chen, C., et al. Structure of a putative NTP pyrophosphohydrolase: YP_001813558.1 from Exiguobacterium sibiricum 255-15 Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1237-1244  DOI:10.1107/s1744309110025534  PMID:20944217  PMCID:PMC2954211
  • Han, G. W., Yang, X. L., McMullan, D., Chong, Y. E., Krishna, S. S., Rife, C. L., Weekes, D., Brittain, S. M., Abdubek, P., Ambing, E., Astakhova, T., Axelrod, H. L., et al. Structure of a tryptophanyl-tRNA synthetase containing an iron-sulfur cluster Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1326-1334  DOI:10.1107/s1744309110037619  PMID:20944229  PMCID:PMC2954223
  • Miller, M. D., Aravind, L., Bakolitsa, C., Rife, C. L., Carlton, D., Abdubek, P., Astakhova, T., Axelrod, H. L., Chiu, H. J., Clayton, T., Deller, M. C., Duan, L. A., et al. Structure of the first representative of Pfam family PF04016 (DUF364) reveals enolase and rossmann-like folds that combine to form a unique active site with a possible role in heavy-metal chelation Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1167-1173  DOI:10.1107/s1744309110007517  PMID:20944207  PMCID:PMC2954201
  • Chiu, H. J., Bakolitsa, C., Skerra, A., Lomize, A., Carlton, D., Miller, M. D., Krishna, S. S., Abdubek, P., Astakhova, T., Axelrod, H. L., Clayton, T., Deller, M. C., et al. Structure of the first representative of pfam family pf09410 (duf2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1153-1159  DOI:10.1107/s1744309109037749  PMID:20944205  PMCID:PMC2954199
  • Xu, Q. P., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Cai, X. H., Carlton, D., Chen, C., Chiu, H. J., Chiu, M., Clayton, T., Das, D., et al. Structure of the γ-D-glutamyl-L-diamino acid endopeptidase YkfC from Bacillus cereus in complex with L-Ala-γ-D-Glu: insights into substrate recognition by NlpC/P60 cysteine peptidases Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1354-1364  DOI:10.1107/s1744309110021214  PMID:20944232  PMCID:PMC2954226
  • Bakolitsa, C., Kumar, A., Jin, K. K., McMullan, D., Krishna, S. S., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Axelrod, H. L., Burra, P., Carlton, D., et al. Structures of the first representatives of Pfam family PF06684 (DUF1185) reveal a novel variant of the Bacillus chorismate mutase fold and suggest a role in amino-acid metabolism Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1182-1189  DOI:10.1107/s1744309109050647  PMID:20944209  PMCID:PMC2954203
  • Han, G. W., Bakolitsa, C., Miller, M. D., Kumar, A., Carlton, D., Najmanovich, R. J., Abdubek, P., Astakhova, T., Axelrod, H. L., Chen, C., Chiu, H. J., Clayton, T., et al. Structures of the first representatives of Pfam family PF06938 (DUF1285) reveal a new fold with repeated structural motifs and possible involvement in signal transduction Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1218-1225  DOI:10.1107/s1744309109050416  PMID:20944214  PMCID:PMC2954208
  • Axelrod, H. L., Das, D., Abdubek, P., Astakhova, T., Bakolitsa, C., Carlton, D., Chen, C., Chiu, H. J., Clayton, T., Deller, M. C., Duan, L. A., Ellrott, K., et al. Structures of three members of Pfam PF02663 (FmdE) implicated in microbial methanogenesis reveal a conserved alpha plus beta core domain and an auxiliary C-terminal treble-clef zinc finger Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1335-1346  DOI:10.1107/s1744309110020166  PMID:20944230  PMCID:PMC2954224
  • Das, D., Finn, R. D., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Cai, X. H., Carlton, D., Chen, C. N., Chiu, H. J., Chiu, M., Clayton, T., et al. The crystal structure of a bacterial sufu-like protein defines a novel group of bacterial proteins that are similar to the n-terminal domain of human sufu Protein Science  2010 19:2131-2140  DOI:10.1002/pro.497  PMID:20836087  PMCID:PMC3005784
  • Das, D., Finn, R. D., Carlton, D., Miller, M. D., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Chen, C., Chiu, H. J., Chiu, M., Clayton, T., et al. The structure of BVU2987 from Bacteroides vulgatus reveals a superfamily of bacterial periplasmic proteins with possible inhibitory function Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1265-1273  DOI:10.1107/s1744309109046788  PMID:20944221  PMCID:PMC2954215
  • Chiu, H. J., Abdubek, P., Astakhova, T., Axelrod, H. L., Carlton, D., Clayton, T., Das, D., Deller, M. C., Duan, L. A., Feuerhelm, J., Grant, J. C., Grzechnik, A., et al. The structure of Haemophilus influenzae prephenate dehydrogenase suggests unique features of bifunctional TyrA enzymes Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1317-1325  DOI:10.1107/s1744309110021688  PMID:20944228  PMCID:PMC2954222
  • Bakolitsa, C., Bateman, A., Jin, K. K., McMullan, D., Krishna, S. S., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Axelrod, H. L., Burra, P., Carlton, D., et al. The structure of Jann_2411 (DUF1470) from Jannaschia sp. at 1.45 A resolution reveals a new fold (the ABATE domain) and suggests its possible role as a transcription regulator Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1198-1204  DOI:10.1107/s1744309109025196  PMID:20944211  PMCID:PMC2954205
  • Das, D., Kozbial, P., Han, G. W., Carlton, D., Jaroszewski, L., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Chen, C., Chiu, H. J., Chiu, M., et al. The structure of KPN03535 (gi vertical bar 152972051), a novel putative lipoprotein from Klebsiella pneumoniae, reveals an OB-fold Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1254-1260  DOI:10.1107/s1744309109018168  PMID:20944219  PMCID:PMC2954213
  • Krishna, S. S., Aravind, L., Bakolitsa, C., Caruthers, J., Carlton, D., Miller, M. D., Abdubek, P., Astakhova, T., Axelrod, H. L., Chiu, H. J., Clayton, T., Deller, M. C., et al. The structure of SSO2064, the first representative of Pfam family PF01796, reveals a novel two-domain zinc-ribbon OB-fold architecture with a potential acyl-CoA-binding role Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1160-1166  DOI:10.1107/s1744309110002514  PMID:20944206  PMCID:PMC2954200
  • Bakolitsa, C., Kumar, A., McMullan, D., Krishna, S. S., Miller, M. D., Carlton, D., Najmanovich, R., Abdubek, P., Astakhova, T., Chiu, H. J., Clayton, T., Deller, M. C., et al. The structure of the first representative of Pfam family PF06475 reveals a new fold with possible involvement in glycolipid metabolism Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1211-1217  DOI:10.1107/s1744309109022684  PMID:20944213  PMCID:PMC2954207
  • Das, D., Grishin, N. V., Kumar, A., Carlton, D., Bakolitsa, C., Miller, M. D., Abdubek, P., Astakhova, T., Axelrod, H. L., Burra, P., Chen, C., Chiu, H. J., et al. The structure of the first representative of Pfam family PF09836 reveals a two-domain organization and suggests involvement in transcriptional regulation Acta Crystallographica Section F-Structural Biology and Crystallization Communications  2010 66:1174-1181  DOI:10.1107/s1744309109022672  PMID:20944208  PMCID:PMC2954202
  • Xu, Q. P., McMullan, D., Abdubek, P., Astakhova, T., Carlton, D., Chen, C., Chiu, H. J., Clayton, T., Das, D., Deller, M. C., Duan, L., Elsliger, M. A., et al. A structural basis for the regulatory inactivation of DnaA Journal of Molecular Biology  2009 385:368-380  DOI:10.1016/j.jmb.2008.10.059  PMID:19000695  PMCID:PMC2667141
  • Das, D., Kozbial, P., Axelrod, H. L., Miller, M. D., McMullan, D., Krishna, S. S., Abdubek, P., Acosta, C., Astakbova, T., Burra, P., Carlton, D., Chen, C., et al. Crystal structure of a novel Sm-like protein of putative cyanophage origin at 2.60 Å resolution Proteins-Structure Function and Bioinformatics  2009 75:296-307  DOI:10.1002/prot.22360  PMID:19173316  PMCID:PMC2785455
  • Xu, Q. P., Rife, C. L., Carlton, D., Miller, M. D., Krishna, S. S., Elsliger, M. A., Abdubek, P., Astakhova, T., Chiu, H. J., Clayton, T., Duan, L., Feuerhelm, J., et al. Crystal structure of a novel archaeal AAA plus ATPase SSO 1545 from Sulfolobus solfataricus Proteins-Structure Function and Bioinformatics  2009 74:1041-1049  DOI:10.1002/prot.22325  PMID:19089981  PMCID:PMC2692486
  • Xu, Q. P., Carlton, D., Miller, M. D., Elsliger, M. A., Krishna, S. S., Abdubek, P., Astakhova, T., Burra, P., Chiu, H. J., Clayton, T., Deller, M. C., Duan, L., et al. Crystal structure of histidine phosphotransfer protein ShpA, an essential regulator of stalk biogenesis in Caulobacter crescentus Journal of Molecular Biology  2009 390:686-698  DOI:10.1016/j.jmb.2009.05.023  PMID:19450606  PMCID:PMC2726009
  • Das, D., Krishna, S. S., McMullan, D., Miller, M. D., Xu, Q., Abdubek, P., Acosta, C., Astakhova, T., Axelrod, H. L., Burra, P., Carlton, D., Chiu, H. J., et al. Crystal structure of the Fic (Filamentation induced by cAMP) family protein SO4266 (gi|24375750) from Shewanella oneidensis MR-1 at 1.6 A resolution Proteins-Structure Function and Bioinformatics  2009 75:264-271  DOI:10.1002/prot.22338  PMID:19127588  PMCID:PMC2674511
  • Renthal, W., Kumar, A., Xiao, G. H., Wilkinson, M., Covington, H. E., Maze, I., Sikder, D., Robison, A. J., LaPlant, Q., Dietz, D. M., Russo, S. J., Vialou, V., et al. Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins Neuron  2009 62:335-348  DOI:10.1016/j.neuron.2009.03.026  PMID:19447090  PMCID:PMC2779727
  • Wilkinson, M. B., Xiao, G., Kumar, A., LaPlant, Q., Renthal, W., Sikder, D., Kodadek, T. J., Nestler, E. J. Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models Journal of Neuroscience  2009 29:7820-7832  DOI:10.1523/jneurosci.0932-09.2009  PMID:19535594  PMCID:PMC2717944
  • Xu, Q., Traag, B. A., Willemse, J., McMullan, D., Miller, M. D., Elsliger, M. A., Abdubek, P., Astakhova, T., Axelrod, H. L., Bakolitsa, C., Carlton, D., Chen, C., et al. Structural and functional characterizations of SsgB, a conserved activator of developmental cell division in morphologically complex actinomycetes Journal of Biological Chemistry  2009 284:25268-25279  DOI:10.1074/jbc.M109.018564  PMID:19567872  PMCID:PMC2757229
  • Xu, Q. P., Sudek, S., McMullan, D., Miller, M. D., Geierstanger, B., Jones, D. H., Krishna, S. S., Spraggon, G., Bursalay, B., Abdubek, P., Acosta, C., Ambing, E., et al. Structural basis of murein peptide specificity of a γ-D-glutamyl-l-diamino acid endopeptidase Structure  2009 17:303-313  DOI:10.1016/j.str.2008.12.008  PMID:19217401  PMCID:PMC2667786
  • Suzuki, H., Forrest, A. R. R., van Nimwegen, E., Daub, C. O., Balwierz, P. J., Irvine, K. M., Lassmann, T., Ravasi, T., Hasegawa, Y., de Hoon, M. J. L., Katayama, S., Schroder, K., et al. The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line Nature Genetics  2009 41:553-562  DOI:10.1038/ng.375  PMID:19377474
  • Kozbial, P., Xu, Q. P., Chiu, H. J., McMullan, D., Krishna, S. S., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Axelrod, H. L., Carlton, D., Clayton, T., et al. Crystal structures of MW1337R and lin2004: Representatives of a novel protein family that adopt a four-helical bundle fold Proteins-Structure Function and Bioinformatics  2008 71:1589-1596  DOI:10.1002/prot.22020  PMID:18324683
  • Zubieta, C., Krishna, S. S., McMullan, D., Miller, M. D., Abdubek, P., Agarwalla, S., Ambing, E., Astakhova, T., Axelrod, H. L., Carlton, D., Chiu, H. J., Clayton, T., et al. Crystal structure of homoserine o-succinyltransferase from bacillus cereus at 2.4 Å resolution Proteins-Structure Function and Bioinformatics  2007 68:999-1005  DOI:10.1002/prot.21208  PMID:17546672
  • Zubieta, C., Krishna, S. S., Kapoor, M., Kozbial, P., McMullan, D., Axelrod, H. L., Miller, M. D., Abdubek, P., Ambing, E., Astakhova, T., Carlton, D., Chiu, H. J., et al. Crystal structures of two novel dye-decolorizing peroxidases reveal a β-barrel fold with a conserved heme-binding motif Proteins-Structure Function and Bioinformatics  2007 69:223-233  DOI:10.1002/prot.21550  PMID:17654545
  • Zubieta, C., Joseph, R., Krishna, S. S., McMullan, D., Kapoor, M., Axelrod, H. L., Miller, M. D., Abdubek, P., Acosta, C., Astakhova, T., Carlton, D., Chiu, H. J., et al. Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA Proteins-Structure Function and Bioinformatics  2007 69:234-243  DOI:10.1002/prot.21673  PMID:17654547
  • Colvis, C. M., Pollock, J. D., Goodman, R. H., Impey, S., Dunn, J., Mandel, G., Champagne, F. A., Mayford, M., Korzus, E., Kumar, A., Renthal, W., Theobald, D. E. H., et al. Epigenetic mechanisms and gene networks in the nervous system Journal of Neuroscience  2005 25:10379-10389  DOI:10.1523/jneurosci.4119-05.2005  PMID:16280577
  • Wang, K., Zhou, X. R., Zhou, Z. M., Tarakji, K., Qin, J. X., Sitges, M., Shiota, T., Forudi, F., Schaub, R. G., Kumar, A., Penn, M. S., Topol, E. J., et al. Recombinant soluble p-selectin glycoprotein ligand-ig (rpsgl-ig) attenuates infarct size and myeloperoxidase activity in a canine model of ischemia-reperfusion Thrombosis and Haemostasis  2002 88:149-154  PMID:12152656
  • Teng, M. H., Yin, J. Y., Vidal, R., Ghiso, J., Kumar, A., Rabenou, R., Shah, A., Jacobson, D. R., Tagoe, C., Gallo, G., Buxbaum, J. Amyloid and nonfibrillar deposits in mice transgenic for wild-type human transthyretin: A possible model for senile systemic amyloidosis Laboratory Investigation  2001 81:385-396  PMID:11310831
  • Buxbaum, J. N., Genega, E. M., Lazowski, P., Kumar, A., Tunick, P. A., Kronzon, I., Gallo, G. R. Infiltrative nonamyloidotic monoclonal immunoglobulin light chain cardiomyopathy: An underappreciated manifestation of plasma cell dyscrasias Cardiology  2000 93:220-228  DOI:10.1159/000007030  PMID:11025347
  • Opalka, N., Tihova, M., Brugidou, C., Kumar, A., Beachy, R. N., Fauquet, C. M., Yeager, M. Structure of native and expanded sobemoviruses by electron cryo-microscopy and image reconstruction Journal of Molecular Biology  2000 303:197-211  DOI:10.1006/jmbi.2000.4043  PMID:11023786
  • Parker, D., Rivera, M., Zor, T., Henrion-Caude, A., Radhakrishnan, I., Kumar, A., Shapiro, L. H., Wright, P. E., Montminy, M., Brindle, P. K. Role of secondary structure in discrimination between constitutive and inducible activators Molecular and Cellular Biology  1999 19:5601-5607  PMID:10409749  PMCID:PMC84412
  • Reddy, V. S., Giesing, H. A., Morton, R. T., Kumar, A., Post, C. B., Brooks, C. L., Johnson, J. E. Energetics of quasiequivalence: computational analysis of protein-protein interactions in icosahedral viruses Biophysical Journal  1998 74:546-558  DOI:10.1016/S0006-3495(98)77813-0  PMID:9449355  PMCID:PMC1299407
  • Kumar, A., Yang, Y. L., Flati, V., Der, S., Kadereit, S., Deb, A., Haque, J., Reis, L., Weissmann, C., Williams, B. R. G. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the pkr gene: Role of irf-1 and nf-kappa b EMBO Journal  1997 16:406-416  DOI:10.1093/emboj/16.2.406  PMID:9029159  PMCID:PMC1169645
  • Kumar, A., Reddy, V. S., Yusibov, V., Chipman, P. R., Hata, Y., Fita, I., Fukuyama, K., Rossmann, M. G., LoeschFries, L. S., Baker, T. S., Johnson, J. E. The structure of alfalfa mosaic virus capsid protein assembled as a T=1 icosahedral particle at 4.0-Å resolution Journal of Virology  1997 71:7911-7916  PMID:9311881  PMCID:PMC192148
  • Yusibov, V., Kumar, A., North, A., Johnson, J. E., LoeschFries, L. S. Purification, characterization, assembly and crystallization of assembled alfalfa mosaic virus coat protein expressed in escherichia coli Journal of General Virology  1996 77:567-573  DOI:10.1099/0022-1317-77-4-567  PMID:8627243
  • Yang, Y. L., Reis, L. F. L., Pavlovic, J., Aguzzi, A., Schafer, R., Kumar, A., Williams, B. R. G., Aguet, M., Weissmann, C. Deficient signaling in mice devoid of double-stranded rna-dependent protein kinase EMBO Journal  1995 14:6095-6106  PMID:8557029  PMCID:PMC394734
  • Tomiyama, Y., Brojer, E., Ruggeri, Z. M., Shattil, S. J., Smiltneck, J., Gorski, J., Kumar, A., Kieberemmons, T., Kunicki, T. J. A molecular model of RGD ligands. Antibody D gene segments that direct specificity for the integrin alpha IIb beta 3 Journal of Biological Chemistry  1992 267:18085-18092  PMID:1517241
  • Kumar, A., Martineztarquino, C., Mariaforte, A., Kumar, P., Alarconsegovia, D., Granados, J., Pandey, J. P., Buxbaum, J., Schur, P. H. Immunoglobulin heavy-chain constant-region gene polymorphism in systemic lupus-erythematosus Arthritis and Rheumatism  1991 34:1553-1556  PMID:1684106
  • Wider, G., Macura, S., Kumar, A., Ernst, R. R., Wuthrich, K. Homonuclear two-dimensional h-1-NMR of proteins - experimental procedures Journal of Magnetic Resonance  1984 56:207-234  DOI:10.1016/0022-2364(84)90099-4
  • Brown, L. R., Braun, W., Kumar, A., Wuthrich, K. High-resolution nuclear magnetic-resonance studies of the conformation and orientation of melittin bound to a lipid-water interface Biophysical Journal  1982 37:319-328  DOI:10.1016/S0006-3495(82)84680-8  PMID:6275926  PMCID:PMC1329145
  • Kumar, A., Wagner, G., Ernst, R. R., Wuthrich, K. Buildup rates of the nuclear overhauser effect measured by two-dimensional proton magnetic-resonance spectroscopy - implications for studies of protein conformation Journal of the American Chemical Society  1981 103:3654-3658  DOI:10.1021/ja00403a008
  • Bosch, C., Kumar, A., Baumann, R., Ernst, R. R., Wuthrich, K. Comparison of selective proton-proton overhauser effects in biological macromolecules observed by one-dimensional and two-dimensional NMR experiments Journal of Magnetic Resonance  1981 42:159-163  DOI:10.1016/0022-2364(81)90021-4
  • Steinmetz, W. E., Moonen, C., Kumar, A., Lazdunski, M., Visser, L., Carlsson, F. H. H., Wuthrich, K. H-1-NMR studies of the conformation of cardiotoxin vii2 from naja-mossambica-mossambica European Journal of Biochemistry  1981 120:467-475  DOI:10.1111/j.1432-1033.1981.tb05725.x  PMID:7333275
  • Baumann, R., Kumar, A., Ernst, R. R., Wuthrich, K. Improvement of 2d noe and 2d correlated spectra by triangular multiplication Journal of Magnetic Resonance  1981 44:76-83  DOI:10.1016/0022-2364(81)90190-6
  • Wagner, G., Kumar, A., Wuthrich, K. Systematic application of two-dimensional h-1-NMR techniques for studies of proteins .2. Combined use of correlated spectroscopy and nuclear overhauser spectroscopy for sequential assignments of backbone resonances and elucidation of polypeptide secondary structures European Journal of Biochemistry  1981 114:375-384  DOI:10.1111/j.1432-1033.1981.tb05157.x  PMID:6163631
  • Kumar, A., Ernst, R. R., Wuthrich, K. A two-dimensional nuclear Overhauser enhancement (2D NOE) experiment for the elucidation of complete proton-proton cross-relaxation networks in biological macromolecules Biochemical and Biophysical Research Communications  1980 95:1-6  DOI:10.1016/0006-291x(80)90695-6  PMID:7417242
  • Nagayama, K., Kumar, A., Wuthrich, K., Ernst, R. R. Experimental-techniques of two-dimensional correlated spectroscopy Journal of Magnetic Resonance  1980 40:321-334  DOI:10.1016/0022-2364(80)90255-3
  • Kumar, A., Wagner, G., Ernst, R. R., Wuthrich, K. Studies of j-connectivities and selective h-1-h-1 overhauser effects in h2o solutions of biological macromolecules by two-dimensional NMR experiments Biochemical and Biophysical Research Communications  1980 96:1156-1163  DOI:10.1016/0006-291x(80)90073-x  PMID:6159893