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Reversal of diabetes-insipidus in brattleboro rats - intrahypothalamic injection of vasopressin messenger-rna

Academic Article
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Overview

authors

  • Jirikowski, G. F.
  • Sanna, Pietro
  • Maciejewskilenoir, D.
  • Bloom, Floyd

publication date

  • February 1992

journal

  • Science  Journal

abstract

  • Messenger RNAs occur within the axons of magnocellular hypothalamic neurons known to secrete oxytocin and vasopressin. In Brattleboro rats, which have a genetic mutation that renders them incapable of vasopressin expression and secretion and thus causes diabetes insipidus, injection into the hypothalamus of purified mRNAs from normal rat hypothalami or of synthetic copies of the vasopressin mRNA leads to selective uptake, retrograde transport, and expression of vasopressin exclusively in the magnocellular neurons. Temporary reversal of their diabetes insipidus (for up to 5 days) can be observed within hours of the injection. Intra-axonal mRNAs may represent an additional category of chemical signals for neurons.

subject areas

  • Animals
  • Arginine Vasopressin
  • Diabetes Insipidus
  • Hypothalamus
  • RNA, Messenger
  • Rats
  • Rats, Brattleboro
  • Water-Electrolyte Balance
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1546298

PubMed ID

  • 1546298
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Additional Document Info

start page

  • 996

end page

  • 998

volume

  • 255

issue

  • 5047

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