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Physiologic concentrations of normal human plasma lipoproteins inhibit the immortalization of peripheral B lymphocytes by the Epstein-Barr virus

Academic Article
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Overview

authors

  • Chisari, Francis
  • Curtiss, Linda
  • Jensen, F. C.

publication date

  • 1981

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Epstein-Barr virus (EBV)-induced immortalization of adult human B lymphocytes is suppressed by physiologic concentrations of human plasma lipoproteins. Several inhibitory mechanisms appear to be operative. First, low density lipoproteins (LDL) directly reduce the ability of EBV to transform human B cells. Second, LDL as well as intermediate and very low density lipoproteins modulate early inductive events rendering the B cell refractory to transforming signals from EBV. Third, LDL also selectively inhibit an EBV-inducible step that occurs within 24 h after transformation. Finally, very low density lipoproteins can abrogate the ongoing, cellular proliferation of EBV-transformed, established B cell lines. The plasma lipoproteins may therefore prevent the emergence of EBV-transformed malignant B cell clones in vivo. Conceivably, on this basis, environmental and genetic influences on plasma lipoprotein concentrations may affect the global distribution of Burkitt's lymphoma, a lymphoid malignancy putatively caused by EBV.

subject areas

  • Animals
  • B-Lymphocytes
  • Cell Division
  • Cell Transformation, Viral
  • Cells, Cultured
  • Herpesvirus 4, Human
  • Humans
  • Lipoproteins
  • Lymphocyte Activation
  • Tumor Virus Infections
  • Virus Replication
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci110260

PubMed ID

  • 6267100
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Additional Document Info

start page

  • 329

end page

  • 336

volume

  • 68

issue

  • 2

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