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Catalyzed oxidative corrosion of porous silicon used as an optical transducer for ligand-receptor interactions

Academic Article
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Overview

authors

  • Voelcker, N. H.
  • Alfonso, I.
  • Ghadiri, M. Reza

publication date

  • July 2008

journal

  • ChemBioChem  Journal

abstract

  • Biosensors fabricated on the nanoscale offer exciting new avenues in the quest for better understanding and characterization of biological systems. Porous silicon is an ideal nanostructured material for the construction of optical transducer matrices because it is easily functionalized with biomolecular probes and displays strong optical interferences. Here, we show that certain transition metal complexes, including nickel(II)cyclam, are able to induce corrosion in porous silicon films rapidly, generating a strong optical interferometric signal that originates from the porous layer. We subsequently exploit this effect to design a transducer for ligand-receptor recognition. With a nickel(II)cyclam derivative as a catalytic label, DNA- and avidin-binding events are detected by time-lapse interferometric reflectance spectroscopy in a fast, simple, and inexpensive fashion.

subject areas

  • Avidin
  • Base Sequence
  • Biotin
  • Catalysis
  • Corrosion
  • DNA Probes
  • Heterocyclic Compounds
  • Interferometry
  • Ligands
  • Nickel
  • Optics and Photonics
  • Oxidation-Reduction
  • Porosity
  • Protein Binding
  • Silicon
  • Staining and Labeling
  • Surface Properties
  • Time Factors
  • Transducers
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Research

keywords

  • biosensors
  • interferometric reflectance
  • ligand-receptor interactions
  • optical transducers
  • oxidation catalysts
  • porous silicon
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Identity

International Standard Serial Number (ISSN)

  • 1439-4227

Digital Object Identifier (DOI)

  • 10.1002/cbic.200800119

PubMed ID

  • 18576449
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Additional Document Info

start page

  • 1776

end page

  • 1786

volume

  • 9

issue

  • 11

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