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Identifier sequences are transcribed specifically in brain

Academic Article
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Overview

authors

  • Gottesfeld, Joel
  • Lerner, Richard
  • Milner, R, J.
  • Sutcliffe, J. Gregor

publication date

  • 1984

journal

  • Nature  Journal

abstract

  • 'Identifier' or ID sequences are present in 62% of the RNA polymerase II and III transcripts made in vitro from brain nuclei but in fewer than 4% of the transcripts made from the nuclei of other tissues. An homologous 160-nucleotide cytoplasmic poly(A)+ RNA species, BC1, and a smaller species, BC2, are located in vivo exclusively in neural tissues. Cloned ID sequences are polymerase III templates in vitro. Our data suggest a model in which brain-specific polymerase III transcription of ID sequences located in introns of brain genes activates those genes in a primary manner for polymerase III transcription.

subject areas

  • Animals
  • Base Sequence
  • Brain
  • Gene Expression Regulation
  • Operon
  • RNA
  • RNA Polymerase II
  • RNA Polymerase III
  • Rats
  • Transcription, Genetic
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Identity

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/308237a0

PubMed ID

  • 6199680
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Additional Document Info

start page

  • 237

end page

  • 241

volume

  • 308

issue

  • 5956

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