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Short communication: Quantitative proteomic plasma profiling reveals activation of host defense to oxidative stress in chronic SIV and methamphetamine comorbidity

Academic Article
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Overview

authors

  • Pendyala, G.
  • Trauger, S. A.
  • Siuzdak, Gary
  • Fox, H. S.

publication date

  • February 2011

journal

  • AIDS Research and Human Retroviruses  Journal

abstract

  • The double epidemic of substance abuse and HIV infection is a multifaceted problem To investigate mechanistic clues to the effects of substance abuse on infected individuals we preformed quantitative proteomic profiling of plasma in a methamphetamine treated nonhuman primate model for AIDS. A nontargeted quantitative approach identified extracellular superoxide dismutase to be significantly upregulated by SIV and methamphetamine treatment, and targeted studies revealed an increase in expression in the antioxidant glutathione S-transferase, thus pointing to a compensatory response to increased oxidative stress in methamphetamine-treated animals.

subject areas

  • Animals
  • Blood Proteins
  • Chronic Disease
  • Humans
  • Methamphetamine
  • Oxidative Stress
  • Proteomics
  • Simian Acquired Immunodeficiency Syndrome
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Identity

PubMed Central ID

  • PMC3045074

International Standard Serial Number (ISSN)

  • 0889-2229

Digital Object Identifier (DOI)

  • 10.1089/aid.2010.0090

PubMed ID

  • 20929344
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Additional Document Info

start page

  • 179

end page

  • 182

volume

  • 27

issue

  • 2

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