recent publications
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academic article
- Guan, Y., Hickey, M. J., Borgstahl, G. E. O., Hallewell, R. A., Lepock, J. R., O'Connor, D., Hsieh, Y. S., Nick, H. S., Silverman, D. N., Tainer, J. A. Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34 Biochemistry 1998 37:4722-4730 DOI:10.1021/bi972394l PMID:9537987
- Fisher, C. L., Cabelli, D. E., Hallewell, R. A., Beroza, P., Lo, T. P., Getzoff, E. D., Tainer, J. A. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase Proteins-Structure Function and Genetics 1997 29:103-112 DOI:10.1002/(sici)1097-0134(199709)29:1<103::aid-prot8>3.0.co;2-g PMID:9294870
- Boissinot, M., Karnas, S., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Getzoff, E. D., Hallewell, R. A. Function of the Greek key connection analysed using circular permutants of superoxide dismutase EMBO Journal 1997 16:2171-2178 DOI:10.1093/emboj/16.9.2171 PMID:9171332 PMCID:PMC1169819
- Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Johnson, M. J., Boissinot, M., Hallewell, R. A., Lepock, J. R., Cabelli, D. E., Tainer, J. A. Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Biochemistry 1996 35:4287-4297 DOI:10.1021/bi951892w PMID:8605177
- Fisher, C. L., Cabelli, D. E., Tainer, J. A., Hallewell, R. A., Getzoff, E. D. The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Proteins-Structure Function and Genetics 1994 19:24-34 DOI:10.1002/prot.340190105 PMID:8066083
- Deng, H. X., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W. Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., Warner, C., Deng, G., et al. Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Science 1993 261:1047-1051 DOI:10.1126/science.8351519 PMID:8351519
- Banci, L., Cabelli, D. E., Getzoff, E. D., Hallewell, R. A., Viezzoli, M. S. An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Journal of Inorganic Biochemistry 1993 50:89-100 DOI:10.1016/0162-0134(93)80016-3 PMID:8098056
- Boissinot, M., Kuhn, L. A., Lee, P., Fisher, C. L., Wang, Y., Hallewell, R. A., Tainer, J. A. Rational design and expression of a heparin-targeted human superoxide-dismutase Biochemical and Biophysical Research Communications 1993 190:250-256 DOI:10.1006/bbrc.1993.1038 PMID:8422249
- Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Beyer, W. F., Hallewell, R. A., Tainer, J. A. The structure of human mitochondrial manganese superoxide-dismutase reveals a novel tetrameric interface of 2 4-helix bundles Cell 1992 71:107-118 DOI:10.1016/0092-8674(92)90270-m PMID:1394426
- Getzoff, E. D., Cabelli, D. E., Fisher, C. L., Parge, H. E., Viezzoli, M. S., Banci, L., Hallewell, R. A. Faster superoxide-dismutase mutants designed by enhancing electrostatic guidance Nature 1992 358:347-351 DOI:10.1038/358347a0 PMID:1353610
- Parge, H. E., Hallewell, R. A., Tainer, J. A. Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Proceedings of the National Academy of Sciences of the United States of America 1992 89:6109-6113 DOI:10.1073/pnas.89.13.6109 PMID:1463506
- Hallewell, R. A., Imlay, K. C., Lee, P., Fong, N. M., Gallegos, C., Getzoff, E. D., Tainer, J. A., Cabelli, D. E., Tekampolson, P., Mullenbach, G. T., Cousens, L. S. Thermostabilization of recombinant human and bovine Cu Zn superoxide dismutases by replacement of free cysteines Biochemical and Biophysical Research Communications 1991 181:474-480 DOI:10.1016/s0006-291x(05)81443-3 PMID:1958215
- Fisher, C. L., Hallewell, R. A., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Free Radical Research Communications 1991 12-3:287-296 DOI:10.3109/10715769109145797 PMID:1649096
- McRee, D. E., Redford, S. M., Getzoff, E. D., Lepock, J. R., Hallewell, R. A., Tainer, J. A. Changes in crystallographic structure and thermostability of a Cu,Zn superoxide-dismutase mutant resulting from the removal of a buried cysteine Journal of Biological Chemistry 1990 265:14234-14241 PMID:2387847
- Hallewell, R. A., Laria, I., Tabrizi, A., Carlin, G., Getzoff, E. D., Tainer, J. A., Cousens, L. S., Mullenbach, G. T. Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives Journal of Biological Chemistry 1989 264:5260-5268 PMID:2647749
- Getzoff, E. D., Tainer, J. A., Stempien, M. M., Bell, G. I., Hallewell, R. A. Evolution of Cu Zn superoxide-dismutase and the Greek key beta-barrel structural motif Proteins-Structure Function and Genetics 1989 5:322-336 DOI:10.1002/prot.340050408 PMID:2798409
- Mullenbach, G. T., Tabrizi, A., Irvine, B. D., Bell, G. I., Tainer, J. A., Hallewell, R. A. Selenocysteines mechanism of incorporation and evolution revealed in cdnas of 3 glutathione peroxidases Protein Engineering 1988 2:239-246 DOI:10.1093/protein/2.3.239 PMID:2976939
- Tainer, J. A., Hallewell, R. A., Roberts, V. A., Parge, H. E., Getzoff, E. D. Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase Basic Life Sciences 1988 49:635-640 DOI:10.1007/978-1-4684-5568-7_100 PMID:3250519
- Parge, H. E., Getzoff, E. D., Scandella, C. S., Hallewell, R. A., Tainer, J. A. Crystallographic characterization of recombinant human CuZn superoxide-dismutase Journal of Biological Chemistry 1986 261:6215-6218 PMID:3782115