recent publications

• academic article

  • Guan, Y., Hickey, M. J., Borgstahl, G. E. O., Hallewell, R. A., Lepock, J. R., O'Connor, D., Hsieh, Y. S., Nick, H. S., Silverman, D. N., Tainer, J. A. Crystal structure of y34f mutant human mitochondrial manganese superoxide dismutase and the functional role of tyrosine 34 Biochemistry  1998 37:4722-4730  DOI:10.1021/bi972394l  PMID:9537987
  • Fisher, C. L., Cabelli, D. E., Hallewell, R. A., Beroza, P., Lo, T. P., Getzoff, E. D., Tainer, J. A. Computational, pulse-radiolytic, and structural investigations of lysine-136 and its role in the electrostatic triad of human Cu,Zn superoxide dismutase Proteins-Structure Function and Genetics  1997 29:103-112  DOI:10.1002/(sici)1097-0134(199709)29:1<103::aid-prot8>3.0.co;2-g  PMID:9294870
  • Boissinot, M., Karnas, S., Lepock, J. R., Cabelli, D. E., Tainer, J. A., Getzoff, E. D., Hallewell, R. A. Function of the Greek key connection analysed using circular permutants of superoxide dismutase EMBO Journal  1997 16:2171-2178  DOI:10.1093/emboj/16.9.2171  PMID:9171332  PMCID:PMC1169819
  • Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Johnson, M. J., Boissinot, M., Hallewell, R. A., Lepock, J. R., Cabelli, D. E., Tainer, J. A. Human mitochondrial manganese superoxide dismutase polymorphic variant ile58thr reduces activity by destabilizing the tetrameric interface Biochemistry  1996 35:4287-4297  DOI:10.1021/bi951892w  PMID:8605177
  • Fisher, C. L., Cabelli, D. E., Tainer, J. A., Hallewell, R. A., Getzoff, E. D. The role of arginine-143 in the electrostatics and mechanism of Cu,Zn superoxide-dismutase - computational and experimental evaluation by mutational analysis Proteins-Structure Function and Genetics  1994 19:24-34  DOI:10.1002/prot.340190105  PMID:8066083
  • Deng, H. X., Hentati, A., Tainer, J. A., Iqbal, Z., Cayabyab, A., Hung, W. Y., Getzoff, E. D., Hu, P., Herzfeldt, B., Roos, R. P., Warner, C., Deng, G., et al. Amyotrophic-lateral-sclerosis and structural defects in Cu,Zn superoxide-dismutase Science  1993 261:1047-1051  DOI:10.1126/science.8351519  PMID:8351519
  • Banci, L., Cabelli, D. E., Getzoff, E. D., Hallewell, R. A., Viezzoli, M. S. An essential role for the conserved Glu-133 in the anion interaction with superoxide-dismutase Journal of Inorganic Biochemistry  1993 50:89-100  DOI:10.1016/0162-0134(93)80016-3  PMID:8098056
  • Boissinot, M., Kuhn, L. A., Lee, P., Fisher, C. L., Wang, Y., Hallewell, R. A., Tainer, J. A. Rational design and expression of a heparin-targeted human superoxide-dismutase Biochemical and Biophysical Research Communications  1993 190:250-256  DOI:10.1006/bbrc.1993.1038  PMID:8422249
  • Borgstahl, G. E. O., Parge, H. E., Hickey, M. J., Beyer, W. F., Hallewell, R. A., Tainer, J. A. The structure of human mitochondrial manganese superoxide-dismutase reveals a novel tetrameric interface of 2 4-helix bundles Cell  1992 71:107-118  DOI:10.1016/0092-8674(92)90270-m  PMID:1394426
  • Getzoff, E. D., Cabelli, D. E., Fisher, C. L., Parge, H. E., Viezzoli, M. S., Banci, L., Hallewell, R. A. Faster superoxide-dismutase mutants designed by enhancing electrostatic guidance Nature  1992 358:347-351  DOI:10.1038/358347a0  PMID:1353610
  • Parge, H. E., Hallewell, R. A., Tainer, J. A. Atomic structures of wild-type and thermostable mutant recombinant human cu,zn superoxide-dismutase Proceedings of the National Academy of Sciences of the United States of America  1992 89:6109-6113  DOI:10.1073/pnas.89.13.6109  PMID:1463506
  • Hallewell, R. A., Imlay, K. C., Lee, P., Fong, N. M., Gallegos, C., Getzoff, E. D., Tainer, J. A., Cabelli, D. E., Tekampolson, P., Mullenbach, G. T., Cousens, L. S. Thermostabilization of recombinant human and bovine Cu Zn superoxide dismutases by replacement of free cysteines Biochemical and Biophysical Research Communications  1991 181:474-480  DOI:10.1016/s0006-291x(05)81443-3  PMID:1958215
  • Fisher, C. L., Hallewell, R. A., Roberts, V. A., Tainer, J. A., Getzoff, E. D. Probing the structural basis for enzyme-substrate recognition in Cu, Zn superoxide dismutase Free Radical Research Communications  1991 12-3:287-296  DOI:10.3109/10715769109145797  PMID:1649096
  • McRee, D. E., Redford, S. M., Getzoff, E. D., Lepock, J. R., Hallewell, R. A., Tainer, J. A. Changes in crystallographic structure and thermostability of a Cu,Zn superoxide-dismutase mutant resulting from the removal of a buried cysteine Journal of Biological Chemistry  1990 265:14234-14241  PMID:2387847
  • Hallewell, R. A., Laria, I., Tabrizi, A., Carlin, G., Getzoff, E. D., Tainer, J. A., Cousens, L. S., Mullenbach, G. T. Genetically engineered polymers of human Cu Zn superoxide-dismutase - biochemistry and serum half-lives Journal of Biological Chemistry  1989 264:5260-5268  PMID:2647749
  • Getzoff, E. D., Tainer, J. A., Stempien, M. M., Bell, G. I., Hallewell, R. A. Evolution of Cu Zn superoxide-dismutase and the Greek key beta-barrel structural motif Proteins-Structure Function and Genetics  1989 5:322-336  DOI:10.1002/prot.340050408  PMID:2798409
  • Mullenbach, G. T., Tabrizi, A., Irvine, B. D., Bell, G. I., Tainer, J. A., Hallewell, R. A. Selenocysteines mechanism of incorporation and evolution revealed in cdnas of 3 glutathione peroxidases Protein Engineering  1988 2:239-246  DOI:10.1093/protein/2.3.239  PMID:2976939
  • Tainer, J. A., Hallewell, R. A., Roberts, V. A., Parge, H. E., Getzoff, E. D. Probing enzyme-substrate recognition and catalytic mechanism in Cu,Zn superoxide dismutase Basic Life Sciences  1988 49:635-640  DOI:10.1007/978-1-4684-5568-7_100  PMID:3250519
  • Parge, H. E., Getzoff, E. D., Scandella, C. S., Hallewell, R. A., Tainer, J. A. Crystallographic characterization of recombinant human CuZn superoxide-dismutase Journal of Biological Chemistry  1986 261:6215-6218  PMID:3782115