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Factor VIII coagulant activity and factor VIII-like antigen: independent molecular entities

Academic Article
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Overview

authors

  • Zimmerman, T. S.
  • Edgington, Thomas

publication date

  • 1973

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Factor VIII coagulant activity (VIII(C)) and the von Willebrand's disease antigen (Factor VIII-like antigen, vW-Ag) are biologically linked, and it has been suggested that they reside on the same molecule. However, insolubilized human isoantibody to VIII(C) and rabbit antiserum containing antibodies to VIII(C) and vW-Ag differentially bind and remove these entities from plasma, thus physically segregating one from the other. These findings indicate that Factor VIII coagulant activity resides on a molecule distinct from that expressing the von Willebrand's antigen.

subject areas

  • Antigen-Antibody Reactions
  • Antigens
  • Blood Coagulation
  • Factor VIII
  • Humans
  • von Willebrand Diseases
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Identity

PubMed Central ID

  • PMC2180567

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.138.4.1015

PubMed ID

  • 4542733
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Additional Document Info

start page

  • 1015

end page

  • 1020

volume

  • 138

issue

  • 4

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