recent publications

• academic article

  • Chen, L. M., Blixt, O., Stevens, J., Lipatov, A. S., Davis, C. T., Collins, B. E., Cox, N. J., Paulson, J. C., Donis, R. O. In vitro evolution of h5n1 avian influenza virus toward human-type receptor specificity Virology  2012 422:105-113  DOI:10.1016/j.virol.2011.10.006  PMID:22056389
  • Maines, T. R., Chen, L. M., Van Hoeven, N., Tumpey, T. M., Blixt, O., Belser, J. A., Gustin, K. M., Pearce, M. B., Pappas, C., Stevens, J., Cox, N. J., Paulson, J. C., et al. Effect of receptor binding domain mutations on receptor binding and transmissibility of avian influenza h5n1 viruses Virology  2011 413:139-147  DOI:10.1016/j.virol.2011.02.015  PMID:21397290
  • Stevens, J., Blixt, O., Chen, L. M., Donis, R. O., Paulson, J. C., Wilson, I. A. Recent avian h5n1 viruses exhibit increased propensity for acquiring human receptor specificity Journal of Molecular Biology  2008 381:1382-1394  DOI:10.1016/j.jmb.2008.04.016  PMID:18672252  PMCID:PMC2519951
  • Astronomo, R. D., Lee, H. K., Scanlan, C. N., Pantophlet, R., Huang, C. Y., Wilson, I. A., Blixt, O., Dwek, R. A., Wong, C. H., Burton, D. R. A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2g12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120 Journal of Virology  2008 82:6359-6368  DOI:10.1128/jvi.00293-08  PMID:18434393  PMCID:PMC2447108
  • Blixt, O., Han, S. F., Liao, L., Zeng, Y., Hoffmann, J., Futakawa, S., Paulson, J. C. Sialoside analogue arrays for rapid identification of high affinity siglec ligands Journal of the American Chemical Society  2008 130:6680-6681  DOI:10.1021/ja80l052g  PMID:18452295  PMCID:PMC2614358
  • Belser, J. A., Blixt, O., Chen, L. M., Pappas, C., Maines, T. R., Van Hoeven, N., Donis, R., Busch, J., McBride, R., Paulson, J. C., Katz, J. M., Tumpey, T. M. Contemporary North American influenza H7 viruses possess human receptor specificity: Implications for virus transmissibility Proceedings of the National Academy of Sciences of the United States of America  2008 105:7558-7563  DOI:10.1073/pnas.0801259105  PMID:18508975  PMCID:PMC2396559
  • Kaltgrad, E., Sen Gupta, S., Punna, S., Huang, C. Y., Chang, A., Wong, C. H., Finn, M. G., Blixt, O. Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold ChemBioChem  2007 8:1455-1462  DOI:10.1002/cbic.200700225  PMID:17676704
  • Stevens, J., Blixt, O., Paulson, J. C., Wilson, I. A. Glycan microarray technologies: Tools to survey host specificity of influenza viruses Nature Reviews Microbiology  2006 4:857-864  DOI:10.1038/nrmicro1530  PMID:17013397
  • Collins, B. E., Blixt, O., Han, S. F., Duong, B., Li, H. Y., Nathan, J. K., Bovin, N., Paulson, J. C. High-affinity ligand probes of cd22 overcome the threshold set by cis ligands for binding, endocytosis, and killing of b cells Journal of Immunology  2006 177:2994-3003  PMID:16920935
  • Paulson, J. C., Blixt, O., Collins, B. E. Sweet spots in functional glycomics Nature Chemical Biology  2006 2:238-248  DOI:10.1038/nchembio785  PMID:16619023
  • Stevens, J., Blixt, O., Tumpey, T. M., Taubenberger, J. K., Paulson, J. C., Wilson, I. A. Structure and receptor specificity of the hemagglutinin from an h5n1 influenza virus Science  2006 312:404-410  DOI:10.1126/science.1124513  PMID:16543414
  • Stevens, J., Blixt, O., Glaser, L., Taubenberger, J. K., Palese, P., Paulson, J. C., Wilson, I. A. Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities Journal of Molecular Biology  2006 355:1143-1155  DOI:10.1016/j.jmb.2005.11.002  PMID:16343533
  • Blixt, O., Vasiliu, D., Allin, K., Jacobsen, N., Warnock, D., Razi, N., Paulson, J. C., Bernatchez, S., Gilbert, M., Wakarchuk, W. Chemoenzymatic synthesis of 2-azidoethyl-ganglio-oligosaccharides gd3, gt3, gm2, gd2, gt2, gm1, and gd1a Carbohydrate Research  2005 340:1963-1972  DOI:10.1016/j.carres.2005.06.008  PMID:16005859
  • Vyas, A. A., Blixt, O., Paulson, J. C., Schnaar, R. L. Potent glycan inhibitors of myelin-associated glycoprotein enhance axon outgrowth in vitro Journal of Biological Chemistry  2005 280:16305-16310  DOI:10.1074/jbc.M500250200  PMID:15701648  PMCID:PMC1852507
  • Blixt, O., Head, S., Mondala, T., Scanlan, C., Huflejt, M. E., Alvarez, R., Bryan, M. C., Fazio, F., Calarese, D., Stevens, J., Razi, N., Stevens, D. J., et al. Printed covalent glycan array for ligand profiling of diverse glycan binding proteins Proceedings of the National Academy of Sciences of the United States of America  2004 101:17033-17038  DOI:10.1073/pnas.0407902101  PMID:15563589  PMCID:PMC534418
  • Shen, Z. X., Go, E. P., Gamez, A., Apon, J. V., Fokin, V., Greig, M., Ventura, M., Crowell, J. E., Blixt, O., Paulson, J. C., Stevens, R. C., Finn, M. G., et al. A mass spectrometry plate reader: monitoring enzyme activity and inhibition with a desorption/ionization on silicon (DIOS) platform ChemBioChem  2004 5:921-927  DOI:10.1002/cbic.200400008  PMID:15239048
  • Collins, B. E., Blixt, O., DeSieno, A. R., Bovin, N., Marth, J. D., Paulson, J. C. Masking of cd22 by cis ligands does not prevent redistribution of cd22 to sites of cell contact Proceedings of the National Academy of Sciences of the United States of America  2004 101:6104-6109  DOI:10.1073/pnas.0400851101  PMID:15079087  PMCID:PMC395930
  • Kalovidouris, S. A., Blixt, O., Nelson, A., Vidal, S., Turnbull, W. B., Paulson, J. C., Stoddart, J. F. Synthetic carbohydrate dendrimers, part 11. Chemically defined sialoside scaffolds for investigation of multivalent interactions with sialic acid binding proteins Journal of Organic Chemistry  2003 68:8485-8493  DOI:10.1021/jo030203g  PMID:14575475
  • Danzer, C. P., Collins, B. E., Blixt, O., Paulson, J. C., Nitschke, L. Transitional and marginal zone b cells have a high proportion of unmasked cd22: Implications for bcr signaling International Immunology  2003 15:1137-1147  DOI:10.1093/intimm/dxg114  PMID:13679384
  • Blixt, O., Collins, B. E., van den Nieuwenhof, I. M., Crocker, P. R., Paulson, J. C. Sialoside specificity of the siglec family assessed using novel multivalent probes - identification of potent inhibitors of myelin-associated glycoprotein Journal of Biological Chemistry  2003 278:31007-31019  DOI:10.1074/jbc.M304331200  PMID:12773526
  • Blixt, O., Paulson, J. C. Biocatalytic preparation of n-glycolylneuraminic acid, deaminoneuraminic acid (kdn) and 9-azido-9-deoxysialic acid oligosaccharides Advanced Synthesis & Catalysis  2003 345:687-690  DOI:10.1002/adsc.200303032
  • Fazio, F., Bryan, M. C., Blixt, O., Paulson, J. C., Wong, C. H. Synthesis of sugar arrays in microtiter plate Journal of the American Chemical Society  2002 124:14397-14402  DOI:10.1021/ja020887u  PMID:12452714
  • Lee, K. J., Mao, S. L., Sun, C. Z., Gao, C., Blixt, O., Arrues, S., Hom, L. G., Kaufmann, G. F., Hoffman, T. Z., Coyle, A. R., Paulson, J., Felding-Habermann, B., et al. Phage-display selection of a human single-chain fv antibody highly specific for melanoma and breast cancer cells using a chemoenzymatically synthesized G(M3)-carbohydrate antigen Journal of the American Chemical Society  2002 124:12439-12446  DOI:10.1021/ja020737j  PMID:12381184
  • Dormitzer, P. R., Sun, Z. Y. J., Blixt, O., Paulson, J. C., Wagner, G., Harrison, S. C. Specificity and affinity of sialic acid binding by the rhesus rotavirus vp8*core Journal of Virology  2002 76:10512-10517  DOI:10.1128/jvi.76.20.10512-10517.2002  PMID:12239329
  • Collins, B. E., Blixt, O., Bovin, N. V., Danzer, C. P., Chui, D., Marth, J. D., Nitschke, L., Paulson, J. C. Constitutively unmasked cd22 on b cells of st6gal i knockout mice: Novel sialoside probe for murine cd22 Glycobiology  2002 12:563-571  DOI:10.1093/glycob/cwf067  PMID:12213789
  • Blixt, O., Allin, K., Pereira, L., Datta, A., Paulson, J. C. Efficient chemoenzymatic synthesis of o-linked sialyl oligosaccharides Journal of the American Chemical Society  2002 124:5739-5746  DOI:10.1021/ja017881+  PMID:12010048
  • Blixt, O., Brown, J., Schur, M. J., Wakarchuk, W., Paulson, J. C. Efficient preparation of natural and synthetic galactosides with a recombinant beta-1,4-galactosyltransferase-/udp-4 '-gal epimerase fusion protein Journal of Organic Chemistry  2001 66:2442-2448  DOI:10.1021/jo0057809  PMID:11281786