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Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5

Academic Article
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Overview

authors

  • Lederman, M. M.
  • Veazey, R. S.
  • Offord, R.
  • Mosier, Donald
  • Dufour, J.
  • Mefford, M.
  • Piatak, M.
  • Lifson, J. D.
  • Salkowitz, J. R.
  • Rodriguez, B.
  • Blauvelt, A.
  • Hartley, O.

publication date

  • October 2004

journal

  • Science  Journal

abstract

  • Topical agents, such as microbicides, that can protect against human immunodeficiency virus (HIV) transmission are urgently needed. Using a chimeric simian/human immunodeficiency virus (SHIV SF162), which is tropic for the chemokine receptor CCR5, we report that topical application of high doses of PSC-RANTES, an amino terminus-modified analog of the chemokine RANTES, provided potent protection against vaginal challenge in rhesus macaques. These experimental findings have potentially important implications for understanding vaginal transmission of HIV and the design of strategies for its prevention.

subject areas

  • Administration, Intravaginal
  • Animals
  • Anti-HIV Agents
  • Anti-Infective Agents, Local
  • Antibodies, Viral
  • CCR5 Receptor Antagonists
  • Chemokine CCL5
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Female
  • HIV Infections
  • HIV-1
  • Macaca mulatta
  • Receptors, CCR5
  • Simian Acquired Immunodeficiency Syndrome
  • Simian Immunodeficiency Virus
  • Vagina
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Identity

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1099288

PubMed ID

  • 15486300
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Additional Document Info

start page

  • 485

end page

  • 487

volume

  • 306

issue

  • 5695

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