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Pathogenesis of cytomegalovirus-infection .1. Activation of virus from bone marrow-derived lymphocytes by in vitro allogenic reaction

Academic Article
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Overview

authors

  • Olding, L. B.
  • Jensen, F. C.
  • Oldstone, Michael

publication date

  • 1975

journal

  • Journal of Experimental Medicine  Journal

abstract

  • After infection in utero or at birth with a cell culture adapted strain of mouse cytomegalovirus (MCMV), several mouse strains developed a latent virus infection in the presence of specific antiviral antibodies. Up to 5 mo after infection, MCMV could be activated and recovered from spleen lymphocytes of the infected animals that were co-cultivated with histoincompatible (H-2 foreign) mouse embryo cells from uninfected animals. In contrast, co-cultivation of lymphoid cells from infected mice with mouse embryo cells from syngeneic, histocompatible (H-2 similar) donors did not activate MCMV. Similarly, MCMV was not recovered from sonicated lymphoid cells. Virus was activated by treating viable lymphoid cells with lipopolysaccharide, a B-cell mitogen, but was not activated by a variety of other mitogens such as phytohemagglutinin, concanavalin A, or pokeweed mitogen. Subsequent purification of lymphoid cells from the infected mice by a variety of techniques indicated that MCMV was harbored in the B-lymphocyte population.

subject areas

  • Animals
  • Antibodies, Viral
  • Bone Marrow Cells
  • Cytomegalovirus
  • Cytomegalovirus Infections
  • Cytopathogenic Effect, Viral
  • Disease Models, Animal
  • Female
  • Fetal Diseases
  • Lymphocyte Activation
  • Lymphocytes
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C3H
  • Mice, Inbred ICR
  • Microscopy, Electron
  • Mitogens
  • Pregnancy
  • Spleen
  • Thymus Gland
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Identity

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.141.3.561

PubMed ID

  • 163887
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Additional Document Info

start page

  • 561

end page

  • 572

volume

  • 141

issue

  • 3

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