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Follicular helper t cells as cognate regulators of b cell immunity

Academic Article
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Overview

authors

  • McHeyzer-Williams, L. J.
  • Pelletier, N.
  • Mark, L.
  • Fazilleau, N.
  • McHeyzer-Williams, Michael G.

publication date

  • June 2009

journal

  • Current Opinion in Immunology  Journal

abstract

  • Follicular helper T (T(FH)) cells are a class of helper T cells specialized in the cognate control of antigen-specific B cell immunity. Upon first contact with antigen-primed B cells, pregerminal center effector T(FH) cells promote B cell clonal expansion, antibody isotype switch, plasma cell differentiation, and the induction of germinal centers. By contrast, within germinal centers, T(FH) cells regulate the fate of antigen-specific GC B cells expressing high-affinity variant B cell receptors to promote memory B cell and long-lived plasma cell development. Recent studies unravel multiple signals controlling T(FH) development and functional subtypes of antigen-specific T(FH) cells, including memory T(FH) cells that accelerate memory B cell responses to antigen rechallenge in vivo.

subject areas

  • Animals
  • B-Lymphocytes
  • Germinal Center
  • Humans
  • Immunity, Cellular
  • Immunologic Memory
  • Lymphocyte Activation
  • Models, Immunological
  • T-Lymphocytes, Helper-Inducer
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Identity

PubMed Central ID

  • PMC2731669

International Standard Serial Number (ISSN)

  • 0952-7915

Digital Object Identifier (DOI)

  • 10.1016/j.coi.2009.05.010

PubMed ID

  • 19502021
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Additional Document Info

start page

  • 266

end page

  • 273

volume

  • 21

issue

  • 3

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