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A comparison of two neurologic scoring instruments for multiple sclerosis

Academic Article
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Overview

authors

  • Koziol, James
  • Frutos, A.
  • Sipe, J. C.
  • Romine, J. S.
  • Beutler, Ernest

publication date

  • March 1996

journal

  • Journal of Neurology  Journal

abstract

  • We examined the degree of association between two neurologic impairment scales, the Extended Disability Status Scale (EDSS) and the Scripps Neurologic Rating Scale (SNRS), with data from a randomized, double-blind, placebo-controlled clinical trial assessing the safety and efficacy of cladribine as treatment for chronic progressive multiple sclerosis (MS). We found that the EDSS and SNRS were not strongly correlated within individual patients, contrary to expectation; moreover, in 9 of the 48 evaluable patients, the directions of their changes from baseline values were not mutually consistent. The scales were differentially sensitive to clinical changes over time, with the EDSS indicating a more abrupt, and the SNRS a more gradual, change in the clinical course of disease. The validity of different impairment scales, and their sensitivity to detect clinical changes, should be formally assessed in future clinical trials using these scales as outcome measures.

subject areas

  • Adult
  • Chronic Disease
  • Cladribine
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Neurologic Examination
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Research

keywords

  • Extended Disability Status Scale
  • Scripps Neurologic Rating Scale
  • cladribine
  • multiple sclerosis
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Identity

International Standard Serial Number (ISSN)

  • 0340-5354

Digital Object Identifier (DOI)

  • 10.1007/bf00868516

PubMed ID

  • 8936349
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Additional Document Info

start page

  • 209

end page

  • 213

volume

  • 243

issue

  • 3

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