Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

Increased expression of the foxp3 functional marker of regulatory t cells following b cell depletion with rituximab in patients with lupus nephritis

Academic Article
uri icon
  • Overview
  • Research
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Sfikakis, P. P.
  • Souliotis, V. L.
  • Fragiadaki, K. G.
  • Moutsopoulos, H. M.
  • Boletis, J. N.
  • Theofilopoulos, Argyrios

publication date

  • April 2007

journal

  • Clinical Immunology  Journal

abstract

  • B cell depletion may affect T cell activation and costimulation status in rituximab-treated patients with SLE. We examined whether rituximab administration in patients with active lupus nephritis is related to changes in mRNA expression of genes that define regulatory T cells (Tregs) in peripheral blood lymphocytes, measured by real-time PCR. At the early phase of B cell depletion mRNA levels of CD25, CTLA-4, GITR and the bona fide Treg functional marker FOXP3 increased significantly in all 7 patients examined. In contrast, mRNA levels of the costimulatory/activation T cell molecule CD40L were profoundly reduced, while mRNA levels of TGF-beta, a cytokine contributing to Treg induction, increased significantly in all. During follow-up, increased FOXP3 mRNA persisted in those patients in clinical remission, while in those patients with active disease subsequent decreases were noted. Further studies should examine whether modulation of Tregs by therapeutic B cell depletion contributes and/or predicts lupus disease remission.

subject areas

  • Adolescent
  • Adult
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • B-Lymphocytes
  • CD40 Ligand
  • Female
  • Forkhead Transcription Factors
  • Gene Expression
  • Humans
  • Immunologic Factors
  • Lupus Nephritis
  • Lymphocyte Activation
  • Lymphocyte Depletion
  • Male
  • RNA, Messenger
  • Remission Induction
  • Reverse Transcriptase Polymerase Chain Reaction
  • Rituximab
  • T-Lymphocytes, Regulatory
  • Transforming Growth Factor beta
scroll to property group menus

Research

keywords

  • B cell
  • CD40L
  • FOXP3
  • T cell
  • TGF-beta
  • autoimmunity
  • lupus
  • nephritis
  • regulatory cells
  • rituximab
  • thymus
scroll to property group menus

Identity

International Standard Serial Number (ISSN)

  • 1521-6616

Digital Object Identifier (DOI)

  • 10.1016/j.clim.2006.12.006

PubMed ID

  • 17275413
scroll to property group menus

Additional Document Info

start page

  • 66

end page

  • 73

volume

  • 123

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support