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Stability, characterization, and kinetics of in-111-labeled monoclonal anti-tumor antibodies in normal animals and nude mouse-human tumor-models

Academic Article
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Overview

authors

  • Halpern, S. E.
  • Hagan, P. L.
  • Garver, P. R.
  • Koziol, James
  • Chen, A. W. N.
  • Frincke, J. M.
  • Bartholomew, R. M.
  • David, G. S.
  • Adams, T. H.

publication date

  • 1983

journal

  • Cancer Research  Journal

abstract

  • Monoclonal antibodies (MoAbs) against carcinoembryonic antigen were successfully radiolabeled with 111In, and the radiopharmaceutical was characterized in vitro and in normal and tumor-bearing mice. The 111In-MoAb proved to be stable in vitro and in vivo under normal conditions, although instability could be induced in vitro with large quantities of iron-free transferrin. Animal distribution studies with 111In-MoAb demonstrated tumor localization superior to 67Ga and pharmacokinetics that were highly similar to those of endogenously labeled 75Se-MoAb. The 111In-MoAb followed first-order kinetics and fit a two-compartmental model when studied in nude mice bearing human colon tumors known to express carcinoembryonic antigen. Significant quantities of radiolabel appeared in tissues other than tumor, with liver and skin having the highest concentrations. Sufficient tumor/background ratios were formed for scanning purposes. The data indicate that 111In-MoAb may prove to be effective as a radiopharmaceutical for tumor imaging.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Carcinoembryonic Antigen
  • Cell Line
  • Colonic Neoplasms
  • Drug Stability
  • Humans
  • Indium
  • Liver
  • Mice
  • Mice, Inbred BALB C
  • Mice, Nude
  • Muscles
  • Neoplasm Transplantation
  • Radioisotopes
  • Tissue Distribution
  • Transplantation, Heterologous
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Identity

International Standard Serial Number (ISSN)

  • 0008-5472

PubMed ID

  • 6616469
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Additional Document Info

start page

  • 5347

end page

  • 5355

volume

  • 43

issue

  • 11

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