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An anticatalytic monoclonal antibody to avian plasminogen activator: its effect on behavior of RSV-transformed chick fibroblasts

Academic Article
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Overview

authors

  • Sullivan, L. M.
  • Quigley, James

publication date

  • June 1986

journal

  • Cell  Journal

abstract

  • A monoclonal antibody has been raised against the serine protease, plasminogen activator (PA) produced by Rous sarcoma virus-transformed chick embryo fibroblasts (RSVCEF), and selected for its ability to inhibit the catalytic activity of PA. The high specificity and anticatalytic nature of the antibody has allowed probing of the direct role of PA in cellular behavior. Microgram quantities of monoclonal IgG inhibit the overgrowth and the morphological changes associated with RSVCEF transformation and the degradation of extracellular matrix mediated by RSVCEF, indicating a catalytic role for PA in these cellular processes. Specific cleavage of extracellular matrix proteins by immunoaffinity-purified PA in the complete absence of plasminogen demonstrates a direct catalytic involvement of PA in matrix degradation.

subject areas

  • Animals
  • Antibodies, Monoclonal
  • Avian Sarcoma Viruses
  • Cell Division
  • Cell Transformation, Neoplastic
  • Cell Transformation, Viral
  • Cells, Cultured
  • Chick Embryo
  • Culture Media
  • Extracellular Matrix
  • Fibroblasts
  • Immunoglobulin G
  • Plasminogen Activators
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Identity

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/0092-8674(86)90565-9

PubMed ID

  • 3011282
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Additional Document Info

start page

  • 905

end page

  • 915

volume

  • 45

issue

  • 6

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