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Coupling of the adhesive receptor cd11b/cd18 to functional enhancement of effector macrophage tissue factor response

Academic Article
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Overview

authors

  • Fan, S. T.
  • Edgington, Thomas

publication date

  • January 1991

journal

  • Journal of Clinical Investigation  Journal

abstract

  • Initiation and regulation of localized selective proteolysis is an important effector property of cells of macrophage (Mo) lineage. Among such effector responses is the induced expression of tissue factor (TF) by cells of Mo lineage. In characterizing the regulation of the Mo responses that may influence the magnitude of the effector phase of the cellular immune response, we have identified a role for the cell surface adhesive receptor CD11b/CD18 (Mac-1, CR3) to amplify the induced TF response. Occupancy of CD11b/CD18 by MAb as surrogate ligands does not directly initiate a TF response. In contrast, after either T cell-derived cytokine or LPS as initial signals, engagement of CD11b/CD18 by MAb induces a two- to eight-fold functional enhancement of the TF response in murine and human Mo. This pathway of CD11b/CD18 enhancement of this Mo effector response was also confirmed with recognized ligands for CD11b/CD18 by exposure of Mo to immobilized fibrinogen. A quantitative increase of Mo surface expression of TF was validated by flow cytometry. We suggest that engagement of CD11b/CD18 by complementary ligands including adherence to extracellular matrix, and possibly in antigen-driven TH:Mo collaborative responses, results in the transduction of cellular signals that quantitatively enhance the expression of TF per se and thereby enhance the inflammatory component of Mo mediated response.

subject areas

  • Animals
  • Antigens, CD
  • Antigens, CD18
  • Blood Coagulation Factors
  • Calcium
  • Factor VII
  • Factor X
  • Humans
  • Lipopolysaccharides
  • Macrophage-1 Antigen
  • Macrophages
  • Mice
  • Mice, Inbred Strains
  • Receptors, Leukocyte-Adhesion
  • Thromboplastin
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Research

keywords

  • ADHESIVE RECEPTOR
  • INTEGRIN
  • MACROPHAGE
  • TISSUE FACTOR
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Identity

International Standard Serial Number (ISSN)

  • 0021-9738

Digital Object Identifier (DOI)

  • 10.1172/jci115000

PubMed ID

  • 1670636
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Additional Document Info

start page

  • 50

end page

  • 57

volume

  • 87

issue

  • 1

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