recent publications
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academic article
- Yegneswaran, S., Banerjee, Y., Fernandez, J. A., Deguchi, H., Griffin, J. H. Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex PLoS One 2015 10:e0135025 DOI:10.1371/journal.pone.0135025 PMID:26263376 PMCID:PMC4532512
- von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis 2012 108:981-991 DOI:10.1160/th12-03-0196 PMID:23052565 PMCID:PMC3597782
- Dirksen, A., Yegneswaran, S., Dawson, P. E. Bisaryl hydrazones as exchangeable biocompatible linkers Angewandte Chemie-International Edition 2010 49:2023-2027 DOI:10.1002/anie.200906756 PMID:20183838 PMCID:PMC4383167
- Yegneswaran, S., Nguyen, P. M., Gale, A. J., Griffin, J. H. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Thrombosis and Haemostasis 2009 101:55-61 DOI:10.1160/th08-07-0491 PMID:19132189 PMCID:PMC2730196
- Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry 2008 283:33046-33052 DOI:10.1074/jbc.M806527200 PMID:18784085 PMCID:PMC2586267
- Yegneswaran, S., Tiefenbrunn, T. K., Fernandez, J. A., Dawson, P. E. Manipulation of thrombin exosite I, by ligand-directed covalent modification Journal of Thrombosis and Haemostasis 2007 5:2062-2069 DOI:10.1111/j.1538-7836.2007.02712.x PMID:17883702
- Yegneswaran, S., Kojima, Y., Nguyen, P. M., Gale, A. J., Heeb, M. J., Griffin, J. H. Factor Va residues 311-325 represent an activated protein C binding region Journal of Biological Chemistry 2007 282:28353-28361 DOI:10.1074/jbc.M704316200 PMID:17646160
- Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., Griffin, J. H. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Journal of Biological Chemistry 2007 282:21848-21855 DOI:10.1074/jbc.M702192200 PMID:17553804
- Yegneswaran, S., Mesters, R. M., Fernandez, J. A., Griffin, J. H. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex Journal of Biological Chemistry 2004 279:49019-49025 DOI:10.1074/jbc.M406654200 PMID:15331602 PMCID:PMC2911622
- Mosnier, L. O., Gale, A. J., Yegneswaran, S., Griffin, J. H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood 2004 104:1740-1744 DOI:10.1182/blood-2004-01-0110 PMID:15178575
- Deguchi, H., Yegneswaran, S., Griffin, J. H. Sphingolipids as bioactive regulators of thrombin generation Journal of Biological Chemistry 2004 279:12036-12042 DOI:10.1074/jbc.M302531200 PMID:14722105
- Yegneswaran, S., Mesters, R. M., Griffin, J. H. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex Journal of Biological Chemistry 2003 278:33312-33318 DOI:10.1074/jbc.M305906200 PMID:12805370
- Yegneswaran, S., Deguchi, H., Griffin, J. H. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Journal of Biological Chemistry 2003 278:14614-14621 DOI:10.1074/jbc.M206746200 PMID:12560338
- Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology 2002 9:485-494 DOI:10.1016/s1074-5521(02)00132-1 PMID:11983337
- Rintelen, C., Yegneswaran, S., Griffin, J. H. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation Thrombosis and Haemostasis 2001 85:274-279 PMID:11246547
- Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal 2000 349:757-764 PMID:10903136 PMCID:PMC1221202