recent publications

• academic article

  • Yegneswaran, S., Banerjee, Y., Fernandez, J. A., Deguchi, H., Griffin, J. H. Lyso-sulfatide binds factor Xa and inhibits thrombin generation by the prothrombinase complex PLoS One  2015 10:e0135025  DOI:10.1371/journal.pone.0135025  PMID:26263376  PMCID:PMC4532512
  • von Drygalski, A., Furlan-Freguia, C., Mosnier, L. O., Yegneswaran, S., Ruf, W., Griffin, J. H. Infrared fluorescence for vascular barrier breach in vivo - a novel method for quantitation of albumin efflux Thrombosis and Haemostasis  2012 108:981-991  DOI:10.1160/th12-03-0196  PMID:23052565  PMCID:PMC3597782
  • Dirksen, A., Yegneswaran, S., Dawson, P. E. Bisaryl hydrazones as exchangeable biocompatible linkers Angewandte Chemie-International Edition  2010 49:2023-2027  DOI:10.1002/anie.200906756  PMID:20183838  PMCID:PMC4383167
  • Yegneswaran, S., Nguyen, P. M., Gale, A. J., Griffin, J. H. Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C Thrombosis and Haemostasis  2009 101:55-61  DOI:10.1160/th08-07-0491  PMID:19132189  PMCID:PMC2730196
  • Yegneswaran, S., Hackeng, T. M., Dawson, P. E., Griffin, J. H. The thrombin-sensitive region of protein S mediates phospholipid-dependent interaction with factor Xa Journal of Biological Chemistry  2008 283:33046-33052  DOI:10.1074/jbc.M806527200  PMID:18784085  PMCID:PMC2586267
  • Yegneswaran, S., Tiefenbrunn, T. K., Fernandez, J. A., Dawson, P. E. Manipulation of thrombin exosite I, by ligand-directed covalent modification Journal of Thrombosis and Haemostasis  2007 5:2062-2069  DOI:10.1111/j.1538-7836.2007.02712.x  PMID:17883702
  • Yegneswaran, S., Kojima, Y., Nguyen, P. M., Gale, A. J., Heeb, M. J., Griffin, J. H. Factor Va residues 311-325 represent an activated protein C binding region Journal of Biological Chemistry  2007 282:28353-28361  DOI:10.1074/jbc.M704316200  PMID:17646160
  • Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., Griffin, J. H. Characterization of a factor Xa binding site on factor Va near the Arg-506 activated protein C cleavage site Journal of Biological Chemistry  2007 282:21848-21855  DOI:10.1074/jbc.M702192200  PMID:17553804
  • Yegneswaran, S., Mesters, R. M., Fernandez, J. A., Griffin, J. H. Prothrombin residues 473-487 contribute to factor Va binding in the prothrombinase complex Journal of Biological Chemistry  2004 279:49019-49025  DOI:10.1074/jbc.M406654200  PMID:15331602  PMCID:PMC2911622
  • Mosnier, L. O., Gale, A. J., Yegneswaran, S., Griffin, J. H. Activated protein C variants with normal cytoprotective but reduced anticoagulant activity Blood  2004 104:1740-1744  DOI:10.1182/blood-2004-01-0110  PMID:15178575
  • Deguchi, H., Yegneswaran, S., Griffin, J. H. Sphingolipids as bioactive regulators of thrombin generation Journal of Biological Chemistry  2004 279:12036-12042  DOI:10.1074/jbc.M302531200  PMID:14722105
  • Yegneswaran, S., Mesters, R. M., Griffin, J. H. Identification of distinct sequences in human blood coagulation factor Xa and prothrombin essential for substrate and cofactor recognition in the prothrombinase complex Journal of Biological Chemistry  2003 278:33312-33318  DOI:10.1074/jbc.M305906200  PMID:12805370
  • Yegneswaran, S., Deguchi, H., Griffin, J. H. Glucosylceramide, a neutral glycosphingolipid anticoagulant cofactor, enhances the interaction of human- and bovine-activated protein C with negatively charged phospholipid vesicles Journal of Biological Chemistry  2003 278:14614-14621  DOI:10.1074/jbc.M206746200  PMID:12560338
  • Yegneswaran, S., Fernandez, J. A., Griffin, J. H., Dawson, P. E. Factor Va increases the affinity of factor Xa for prothrombin: a binding study using a novel photoactivable thiol-specific fluorescent probe Chemistry & Biology  2002 9:485-494  DOI:10.1016/s1074-5521(02)00132-1  PMID:11983337
  • Rintelen, C., Yegneswaran, S., Griffin, J. H. Anticoagulant dysfunction of human Arg352Trp-activated protein C caused by defective factor Va inactivation Thrombosis and Haemostasis  2001 85:274-279  PMID:11246547
  • Hackeng, T. M., Yegneswaran, S., Johnson, A. E., Griffin, J. H. Conformational changes in activated protein C caused by binding of the first epidermal growth factor-like module of protein S Biochemical Journal  2000 349:757-764  PMID:10903136  PMCID:PMC1221202