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Low protein Z levels and risk of ischemic stroke: differences by diabetic status and gender

Academic Article
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Overview

authors

  • Heeb, Mary Jo
  • Paganini-Hill, A.
  • Griffin, John
  • Fisher, M.

publication date

  • September 2002

journal

  • Blood Cells Molecules and Diseases  Journal

abstract

  • Protein Z was recently shown to act as an essential cofactor for protein Z-dependent protease inhibitor, a potent downregulator of coagulation Factor Xa. Thus, deficiency of protein Z is hypothesized to lead to a prothrombotic state, but two publications reported opposing results for the relationship of protein Z levels with ischemic stroke in young European subjects (mean age 33-40 years). We performed a study of stroke in a different ethnic population of greater mean age (57 years) to further clarify this issue. An ELISA was developed to measure protein Z antigen in 154 patients with ischemic stroke and in 206 controls in a largely Hispanic population. Low plasma protein Z values were significantly associated with ischemic stroke except in diabetic subjects and females. The mean protein Z value was significantly lower in stroke cases than in controls for nondiabetic subjects [1.78 +/- 0.77 (S.D.) versus 2.28 +/- 0.88 microg/ml, P < 0.0001] and for males (1.90 +/- 0.90 versus 2.42 +/- 0.99 microg/ml, P = 0.0004). Stroke risk was higher in subjects with protein Z levels at or below the fifteenth percentile of controls (

subject areas

  • Adult
  • Aged
  • Aged, 80 and over
  • Blood Proteins
  • Case-Control Studies
  • Diabetes Complications
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Hispanic Americans
  • Humans
  • Ischemia
  • Male
  • Middle Aged
  • Risk Factors
  • Sex Factors
  • Stroke
  • United States
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Research

keywords

  • cerebral ischemia
  • protein Z
  • stroke
  • thrombosis
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Identity

International Standard Serial Number (ISSN)

  • 1079-9796

Digital Object Identifier (DOI)

  • 10.1006/bcmd.2002.0549

PubMed ID

  • 12490280
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Additional Document Info

start page

  • 139

end page

  • 144

volume

  • 29

issue

  • 2

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