Scripps VIVO scripps research logo

  • Index
  • Log in
  • Home
  • People
  • Organizations
  • Research
  • Events
Search form
As of April 1st VIVO Scientific Profiles will no longer updated for faculty, and the link to VIVO will be removed from the library website. Faculty profile pages will continue to be updated via Interfolio. VIVO will continue being used behind the scenes to update graduate student profiles. Please contact helplib@scripps.edu if you have questions.
How to download citations from VIVO | Alternative profile options

The effect of induced chronic viral infections on the immunologic diseases of new zealand mice

Academic Article
uri icon
  • Overview
  • Identity
  • Additional Document Info
  • View All
scroll to property group menus

Overview

authors

  • Tonietti, G.
  • Oldstone, Michael
  • Dixon, F. J.

publication date

  • 1970

journal

  • Journal of Experimental Medicine  Journal

abstract

  • Chronic infections induced at birth with either LCM, an RNA virus, or polyoma, a DNA virus, in NZB, NZW, and NZB x W mice enhance ANA formation, aggravate the immune complex glomerulonephritis, and increase the associated mortality. The ANA titer was increased without apparent change in specificity of the antibodies involved in all three types of mice. Glomerulonephritis, while more severe in infected mice, was of the same type as occurred spontaneously and was characterized by a granular to lumpy accumulation of host IgG and C3 in the mesangia and along the capillary walls of the glomeruli. Of the LCM infected mice of all three types over 50% had died of glomerulonephritis by 6 months and over 85% by 9 months. Of the polyoma infected mice of all three types approximately 20% had died of glomerulonephritis by 6 months and over 40% by 9 months. Of the uninfected controls of all three types less than 10% had died by 6 months and less than 20% at 9 months except for the NZB x W females which had a 67% mortality at 9 months as a result of their spontaneous glomerulonephritis. The two viral infections had significant effect on the incidence of anti-red cell antibodies or the severity of autoimmune hemolytic anemia in any of the three NZ mice.

subject areas

  • Anemia, Hemolytic, Autoimmune
  • Animals
  • Antibodies, Antinuclear
  • Antibody Formation
  • Autoantibodies
  • Autoimmune Diseases
  • Chronic Disease
  • Complement System Proteins
  • Coombs Test
  • DNA Viruses
  • Female
  • Fluorescent Antibody Technique
  • Glomerulonephritis
  • Hematocrit
  • Histocytochemistry
  • Immunodiffusion
  • Immunoglobulin G
  • Kidney Glomerulus
  • Male
  • Mice
  • Polyomavirus
  • Proteinuria
  • RNA Viruses
  • Species Specificity
  • Virus Diseases
scroll to property group menus

Identity

PubMed Central ID

  • PMC2138747

International Standard Serial Number (ISSN)

  • 0022-1007

Digital Object Identifier (DOI)

  • 10.1084/jem.132.1.89

PubMed ID

  • 4323748
scroll to property group menus

Additional Document Info

start page

  • 89

end page

  • 109

volume

  • 132

issue

  • 1

©2022 The Scripps Research Institute | Terms of Use | Powered by VIVO

  • About
  • Contact Us
  • Support