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Synthesis of isochrysohermidin-distamycin hybrids

Academic Article
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Overview

authors

  • Yeung, B. K. S.
  • Boger, Dale

publication date

  • June 2003

journal

  • Journal of Organic Chemistry  Journal

abstract

  • The synthesis of the alkylating subunit of the DNA cross-linking agent, isochrysohermidin (2), and its subsequent incorporation into conjugates with distamycin A (1) are described. The DNA binding properties of these agents were compared to that of distamycin A, using a fluorescence intercalator displacement (FID) assay.

subject areas

  • Algorithms
  • Alkylation
  • Combinatorial Chemistry Techniques
  • Cross-Linking Reagents
  • DNA
  • Distamycins
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
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Identity

International Standard Serial Number (ISSN)

  • 0022-3263

Digital Object Identifier (DOI)

  • 10.1021/jo034326c

PubMed ID

  • 12816485
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Additional Document Info

start page

  • 5249

end page

  • 5253

volume

  • 68

issue

  • 13

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