Synthesis of isochrysohermidin-distamycin hybrids

Academic Article

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Overview

authors

• Yeung, B. K. S.
• Boger, Dale

publication date

• 2003

journal

• Journal of Organic Chemistry  Journal

abstract

• The synthesis of the alkylating subunit of the DNA cross-linking agent, isochrysohermidin (2), and its subsequent incorporation into conjugates with distamycin A (1) are described. The DNA binding properties of these agents were compared to that of distamycin A, using a fluorescence intercalator displacement (FID) assay.

subject areas

• Algorithms
• Alkylation
• Combinatorial Chemistry Techniques
• Cross-Linking Reagents
• DNA
• Distamycins
• Magnetic Resonance Spectroscopy
• Molecular Structure

Identity

International Standard Serial Number (ISSN)

• 0022-3263

Digital Object Identifier (DOI)

• 10.1021/jo034326c

PubMed ID

• 12816485

Additional Document Info

start page

• 5249

end page

• 5253

volume

• 68

issue

• 13